Recombinant Human ZNF268 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF268 also known as Zinc Finger Protein 268 is a transcription factor with a molecular mass around 90 kDa. It includes several zinc finger motifs that enable binding to DNA. By modifying gene expression ZNF268 plays a role in cell differentiation and development. Expression of ZNF268 occurs in various tissues including liver lung and skeletal muscle.

Biological function summary

ZNF268 contributes to the regulation of transcription by binding specific DNA sequences. This process involves recognizing and interacting with promoter regions on genes controlling their expression. ZNF268 does not form part of a multi-protein complex typically but it can influence expression of various genes involved in cellular growth and differentiation.

Pathways

With regards to pathways cellular proliferation and differentiation rely on ZNF268 activity. It plays a role in the Notch signaling pathway important for cell communication that affects cell fate decisions. ZNF268 also interacts with proteins like HES1 which mediates the effects of the Notch pathway. Such interactions help integrate signaling networks during development and tissue homeostasis.

Studies link ZNF268 to certain cancers and developmental disorders. Aberrant expression of ZNF268 may contribute to oncogenesis as its overexpression is observed in some tumor cells. Altered ZNF268 activity also associates with developmental anomalies possibly through its interactions with key regulatory proteins such as MYC. These connections suggest that ZNF268 could be significant in both normal development and pathogenesis.