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Recombinant Human ZNF32 protein (denatured) is a Human Full Length protein, in the 1 to 273 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.

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Images

SDS-PAGE - Recombinant Human ZNF32 protein (denatured) (AB181934), expandable thumbnail

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

Biologically active

No

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M G S M F G F P T A T L L D C H G R Y A Q N V A F F N V M T E A H H K Y D H S E A T G S S S W D I Q N S F R R E K L E Q K S P D S K T L Q E D S P G V R Q R V Y E C Q E C G K S F R Q K G S L T L H E R I H T G Q K P F E C T H C G K S F R A K G N L V T H Q R I H T G E K P Y Q C K E C G K S F S Q R G S L A V H E R L H T G Q K P Y E C A I C Q R S F R N Q S N L A V H R R V H S G E K P Y R C D Q C G K A F S Q K G S L I V H I R V H T G L K P Y A C T Q C R K S F H T R G N C I L H G K I H T G E T P Y L C G Q C G K S F T Q R G S L A V H Q R S C S Q R L T L

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

May be involved in transcriptional regulation.

Alternative names

Recommended products

Recombinant Human ZNF32 protein (denatured) is a Human Full Length protein, in the 1 to 273 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Applications

SDS-PAGE

Accession
P17041-1
Animal free

No

Species

Human

Concentration
Loading...
Storage buffer

pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

Sequence info

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M G S M F G F P T A T L L D C H G R Y A Q N V A F F N V M T E A H H K Y D H S E A T G S S S W D I Q N S F R R E K L E Q K S P D S K T L Q E D S P G V R Q R V Y E C Q E C G K S F R Q K G S L T L H E R I H T G Q K P F E C T H C G K S F R A K G N L V T H Q R I H T G E K P Y Q C K E C G K S F S Q R G S L A V H E R L H T G Q K P Y E C A I C Q R S F R N Q S N L A V H R R V H S G E K P Y R C D Q C G K A F S Q K G S L I V H I R V H T G L K P Y A C T Q C R K S F H T R G N C I L H G K I H T G E T P Y L C G Q C G K S F T Q R G S L A V H Q R S C S Q R L T L

Accession

P17041

Protein length

Full Length

Predicted molecular weight

33.4 kDa

Amino acids

1 to 273

Nature

Recombinant

Tags

His tag N-Terminus

Specifications

Form

Liquid

General info

Function

May be involved in transcriptional regulation.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Subcellular localisation

Nucleus

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ZNF32 also known as Zinc Finger Protein 32 acts mechanically as a transcription factor. This protein with a molecular mass around 59 kDa binds to specific DNA sequences influencing gene expression. Researchers have identified its robust expression in several tissues including the brain liver and spleen. ZNF32 plays a role in gene regulation and its zinc finger motifs allow it to interact with DNA enabling transcriptional regulation functions.

Biological function summary

ZNF32 regulates the expression of various genes involved in cell survival and apoptosis. It does not form part of a known complex but its activity influences important cellular processes. This regulatory capacity impacts cellular responses to stress and contributes to homeostasis within different cellular environments. Its ability to modulate gene expression links it to the control of cell proliferation and differentiation.

Pathways

ZNF32 becomes important in the apoptosis and cell cycle regulation pathways. It interacts with other transcription factors and proteins like p53 in apoptosis signaling pathways. This involvement in the recycling of cellular components places ZNF32 in direct relation with multiple signaling cascades that sustain cellular function and survival. These interactions highlight its necessity in maintaining cellular integrity and preventing unwanted cell death.

Associated diseases and disorders

ZNF32 shows association with cancer and neurodegenerative disorders. Aberrant expression or mutations in the ZNF32 gene may correlate with increased tumorigenesis largely through its interaction with p53 during apoptosis. ZNF32 also demonstrates a connection to Alzheimer's disease likely influencing pathways with associated proteins like tau. Understanding these interactions aids in recognizing how ZNF32 modifications can contribute to pathology.

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1 product image

  • SDS-PAGE - Recombinant Human ZNF32 protein (denatured) (ab181934), expandable thumbnail

    SDS-PAGE - Recombinant Human ZNF32 protein (denatured) (ab181934)

    15% SDS-PAGE analysis of 3 μg ab181934.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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