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AB181934

Recombinant Human ZNF32 protein (denatured)

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Recombinant Human ZNF32 protein (denatured) is a Human Full Length protein, in the 1 to 273 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

KOX30, ZNF32, Zinc finger protein 32, C2H2-546, Zinc finger protein KOX30

1 Images
SDS-PAGE - Recombinant Human ZNF32 protein (denatured) (AB181934)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ZNF32 protein (denatured) (AB181934)

15% SDS-PAGE analysis of 3 μg ab181934.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P17041

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMFGFPTATLLDCHGRYAQNVAFFNVMTEAHHKYDHSEATGSSSWDIQNSFRREKLEQKSPDSKTLQEDSPGVRQRVYECQECGKSFRQKGSLTLHERIHTGQKPFECTHCGKSFRAKGNLVTHQRIHTGEKPYQCKECGKSFSQRGSLAVHERLHTGQKPYECAICQRSFRNQSNLAVHRRVHSGEKPYRCDQCGKAFSQKGSLIVHIRVHTGLKPYACTQCRKSFHTRGNCILHGKIHTGETPYLCGQCGKSFTQRGSLAVHQRSCSQRLTL","proteinLength":"Full Length","predictedMolecularWeight":"33.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":273,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P17041","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF32 also known as Zinc Finger Protein 32 acts mechanically as a transcription factor. This protein with a molecular mass around 59 kDa binds to specific DNA sequences influencing gene expression. Researchers have identified its robust expression in several tissues including the brain liver and spleen. ZNF32 plays a role in gene regulation and its zinc finger motifs allow it to interact with DNA enabling transcriptional regulation functions.
Biological function summary

ZNF32 regulates the expression of various genes involved in cell survival and apoptosis. It does not form part of a known complex but its activity influences important cellular processes. This regulatory capacity impacts cellular responses to stress and contributes to homeostasis within different cellular environments. Its ability to modulate gene expression links it to the control of cell proliferation and differentiation.

Pathways

ZNF32 becomes important in the apoptosis and cell cycle regulation pathways. It interacts with other transcription factors and proteins like p53 in apoptosis signaling pathways. This involvement in the recycling of cellular components places ZNF32 in direct relation with multiple signaling cascades that sustain cellular function and survival. These interactions highlight its necessity in maintaining cellular integrity and preventing unwanted cell death.

ZNF32 shows association with cancer and neurodegenerative disorders. Aberrant expression or mutations in the ZNF32 gene may correlate with increased tumorigenesis largely through its interaction with p53 during apoptosis. ZNF32 also demonstrates a connection to Alzheimer's disease likely influencing pathways with associated proteins like tau. Understanding these interactions aids in recognizing how ZNF32 modifications can contribute to pathology.
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Specifications

Form

Liquid

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General info

Function

May be involved in transcriptional regulation.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

May be involved in transcriptional regulation.
See full target information ZNF32
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