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AB127782

Recombinant Human ZNF337 protein (His-DHFR tag N-Terminus)

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Recombinant Human ZNF337 protein (His-DHFR tag N-Terminus) is a Human Fragment protein, in the 189 to 451 aa range, expressed in Escherichia coli, with 80%, suitable for SDS-PAGE.

View Alternative Names

Zinc finger protein 337, ZNF337

Key facts

Purity

80%

Expression system

Escherichia coli

Tags

His-DHFR tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9Y3M9

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in 50 µL of water

Storage buffer

Constituents: 0.58% Sodium chloride, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"","proteinLength":"Fragment","predictedMolecularWeight":"30.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":451,"aminoAcidStart":189,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"Q9Y3M9","tags":[{"tag":"His-DHFR","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF337 also known as Zinc Finger Protein 337 is a protein that plays a role in transcriptional regulation. This protein consists of zinc finger motifs which enables it to bind to DNA sequences. ZNF337 has a molecular mass of approximately 61 kDa. It is expressed in various tissues including the brain and liver suggesting a broad role in cellular processes across different systems. The presence of zinc finger domains indicates its involvement in DNA-binding and gene expression modulation.
Biological function summary

ZNF337 acts in the regulation of gene expression. It may bind to specific DNA regions influencing the transcription of genes that are critical in cellular differentiation and development. ZNF337 could form part of a transcriptional complex cooperating with other transcription factors to finely regulate the expression levels of target genes. It could influence cell fate and development by managing gene accessibility and expression.

Pathways

ZNF337 operates within the transcriptional regulation pathways affecting gene expression and cellular functions. This protein may interact with the Notch signaling pathway which is known for its roles in cell differentiation and development. ZNF337 might also be associated with other zinc finger proteins such as ZNF143 that are deeply embedded in transcriptional networks. These connections suggest a broad influence on cellular function and development through modulation of signaling and regulatory pathways.

Research links ZNF337 to neurodevelopmental disorders and cancer. Mutations or dysregulation in ZNF337 may lead to improper function of the protein which can contribute to the development of certain neurodevelopmental anomalies. Additionally aberrant expression of ZNF337 correlates with tumor progression in cancer. Its interactions with transcription factors and other zinc finger proteins such as ZNF423 have potential implications in these diseases making ZNF337 a target for further investigation in therapeutic strategies.
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Specifications

Form

Lyophilized

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General info

Function

May be involved in transcriptional regulation.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

May be involved in transcriptional regulation.
See full target information ZNF337
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Product promise

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