Recombinant Human ZNF337 protein is a Human Fragment protein, in the 189 to 451 aa range, expressed in Escherichia coli, with =80% purity and suitable for SDS-PAGE.
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Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Zinc finger protein 337, ZNF337
Recombinant Human ZNF337 protein is a Human Fragment protein, in the 189 to 451 aa range, expressed in Escherichia coli, with =80% purity and suitable for SDS-PAGE.
Constituents: 0.58% Sodium chloride, 0.32% Tris HCl
May be involved in transcriptional regulation.
Belongs to the krueppel C2H2-type zinc-finger protein family.
ZNF337 also known as Zinc Finger Protein 337 is a protein that plays a role in transcriptional regulation. This protein consists of zinc finger motifs which enables it to bind to DNA sequences. ZNF337 has a molecular mass of approximately 61 kDa. It is expressed in various tissues including the brain and liver suggesting a broad role in cellular processes across different systems. The presence of zinc finger domains indicates its involvement in DNA-binding and gene expression modulation.
ZNF337 acts in the regulation of gene expression. It may bind to specific DNA regions influencing the transcription of genes that are critical in cellular differentiation and development. ZNF337 could form part of a transcriptional complex cooperating with other transcription factors to finely regulate the expression levels of target genes. It could influence cell fate and development by managing gene accessibility and expression.
ZNF337 operates within the transcriptional regulation pathways affecting gene expression and cellular functions. This protein may interact with the Notch signaling pathway which is known for its roles in cell differentiation and development. ZNF337 might also be associated with other zinc finger proteins such as ZNF143 that are deeply embedded in transcriptional networks. These connections suggest a broad influence on cellular function and development through modulation of signaling and regulatory pathways.
Research links ZNF337 to neurodevelopmental disorders and cancer. Mutations or dysregulation in ZNF337 may lead to improper function of the protein which can contribute to the development of certain neurodevelopmental anomalies. Additionally aberrant expression of ZNF337 correlates with tumor progression in cancer. Its interactions with transcription factors and other zinc finger proteins such as ZNF423 have potential implications in these diseases making ZNF337 a target for further investigation in therapeutic strategies.
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