JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB171689

Recombinant Human ZNF346 protein (His tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human ZNF346 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 294 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

JAZ, ZNF346, Zinc finger protein 346, Just another zinc finger protein

1 Images
SDS-PAGE - Recombinant Human ZNF346 protein (His tag N-Terminus) (AB171689)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ZNF346 protein (His tag N-Terminus) (AB171689)

15% SDS-PAGE analysis of ab171689 (3µg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9UL40

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 50% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMEYPAPATVQAADGGAAGPYSSSELLEGQEPDGVRFDRERARRLWEAVSGAQPVGREEVEHMIQKNQCLFTNTQCKVCCALLISESQKLAHYQSKKHANKVKRYLAIHGMETLKGETKKLDSDQKSSRSKDKNQCCPICNMTFSSPVVAQSHYLGKTHAKNLKLKQQSTKVEALHQNREMIDPDKFCSLCHATFNDPVMAQQHYVGKKHRKQETKLKLMARYGRLADPAVTDFPAGKGYPCKTCKIVLNSIEQYQAHVSGFKHKNQSPKTVASSLGQIPMQRQPIQKDSTTLED","proteinLength":"Full Length","predictedMolecularWeight":"35.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":294,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9UL40","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF346 also known as Zinc Finger Protein 346 or PNOZ is a small protein with a mass of approximately 34 kDa. This protein contains zinc finger motifs which allow it to bind RNA and influence RNA stability and processing. You can find ZNF346 mainly expressed in the nucleus especially in tissues with high metabolic activity like the brain and muscle. Its main mechanical role is mediating interactions with nucleic acids anchoring itself to RNA through zinc finger domains which are important for its biological functions.
Biological function summary

ZNF346 impacts several processes involving RNA. It participates in cellular mechanisms that preserve RNA integrity and modulate RNA metabolism. ZNF346 often acts as part of larger protein complexes that are important for RNA surveillance and decay pathways. These processes help manage the vast array of RNA transcripts ensuring that only correctly assembled RNA molecules advance to translation. It plays a role in maintaining the stability and efficient functioning of the cellular transcriptome.

Pathways

The protein ZNF346 is an integral component of RNA processing pathways. It has significant interactions within the nonsense-mediated decay (NMD) pathway working alongside proteins such as UPF1 which is an important regulator in this pathway. The role of ZNF346 in RNA decay pathways indicates its involvement in safeguarding the cell from erroneous RNA guaranteeing that faulty transcripts do not disrupt protein synthesis.

ZNF346 associations include neurodegenerative and muscular disorders. Alterations in ZNF346 function might link to brain neurodegeneration due to its expression and activity in brain tissues. It shares functional pathways with proteins such as UPF1 in the context of neurodegenerative processes which involves RNA stability. Furthermore abnormalities in ZNF346 activity could influence muscle tissue homeostasis potentially connecting to muscular dystrophies.
style
left-column

Specifications

Form

Liquid

Additional notes

ab171689 is purified using conventional chromatography techniques.

style
left-column

General info

Function

Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed : 24521053). May bind to specific miRNA hairpins (PubMed : 28431233).

Subcellular localisation

Nucleus

style
left-column

Product protocols

style
left-column

Target data

Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed : 24521053). May bind to specific miRNA hairpins (PubMed : 28431233).
See full target information ZNF346
style
left-column
style
left-column
style
right-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Secondary Antibodies

AB102199

Rabbit Anti-Rat IgG+IgM+IgA H&L (HRP)

  • 0
  • 0
Proteins & Peptides

AB196085

Recombinant Human ZBTB9 protein (His tag)

  • 0
  • 0
Secondary Antibodies

AB150095

Goat Anti-Rabbit IgM mu chain (Alexa Fluor® 647)

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Goat Anti-Rabbit IgM mu chain (Alexa Fluor® 647) (AB150095)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com