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AB165455

Recombinant Human ZNF358 protein

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Recombinant Human ZNF358 protein is a Human Full Length protein, in the 1 to 481 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

Zinc finger protein 358, ZNF358

1 Images
SDS-PAGE - Recombinant Human ZNF358 protein (AB165455)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human ZNF358 protein (AB165455)

ab165455 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9NW07

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSSSFDLDPDVIGPVPLILDPNSDTLSPGDPKVDPISSGLTATPQVLATSPAVLPAPASPPRPFSCPDCGRAFRRSSGLSQHRRTHSGEKPYRCPDCGKSFSHGATLAQHRGIHTGARPYQCAACGKAFGWRSTLLKHRSSHSGEKPHHCPVCGKAFGHGSLLAQHLRTHGGPRPHKCPVCAKGFGQGSALLKHLRTHTGERPYPCPQCGKAFGQSSALLQHQRTHTAERPYRCPHCGKAFGQSSNLQHHLRIHTGERPYACPHCSKAFGQSSALLQHLHVHSGERPYRCQLCGKAFGQASSLTKHKRVHEGAAAAAAAAAAAAAAAAAGLGLGPGLSPASMMRPGQVSLLGPDAVSVLGSGLGLSPGTSSGRNPDPGSGPGTLPDPSSKPLPGSRSTPSPTPVESSDPKAGHDAGPDLVPSPDLDPVPSPDPDPVPSPDPNPVSCPDPCSPTRGTVSPALPTGESPEWVQEQGALLGPDG","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":481,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9NW07","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF358 also known as ZFP358 is a zinc finger protein playing a role in gene transcription regulation. It has a molecular mass of approximately 85 kDa. This protein is known to bind DNA in a sequence-specific manner using the zinc finger motifs to function as a transcription factor. ZNF358 expression occurs in multiple tissues with research indicating significant levels in the brain and heart. The protein's mechanical action involves modulating the transcription of specific genes impacting various biological processes.
Biological function summary

ZNF358 modulates critical processes in cellular differentiation and development. As a member of the transcription factor family ZNF358 does not form part of a known multi-protein complex. Instead it functions independently influencing the transcription of genes involved in cellular responses and structural development. This protein plays a role in maintaining cellular homeostasis affecting developmental stages by activating or repressing target gene transcription.

Pathways

ZNF358 influences several notably the Wnt signaling pathway and the Notch signaling pathway. In the Wnt signaling pathway ZNF358 interacts with proteins involved in cellular growth and differentiation such as β-catenin. This pathway plays a significant role in embryonic development and tissue regeneration. In relation to Notch signaling ZNF358 interacts with pathway components influencing cell fate determination and neural development collaborating with proteins like Notch receptors.

ZNF358 shows associations with developmental disorders particularly related to neural and cardiac malformations. Aberrant expression or dysfunction of ZNF358 may contribute to conditions like congenital heart defects due to its impact on cardiac development genes. Additionally disrupted ZNF358 function has links to neurodevelopmental disorders influencing neural pathway genes. Any interactions leading to disease often involve other transcription factors that interact with this protein in the developmental pathways.
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Specifications

Form

Liquid

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General info

Function

May be involved in transcriptional regulation.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

May be involved in transcriptional regulation.
See full target information ZNF358
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