Recombinant Human ZNF404 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF404 also known as Zinc Finger Protein 404 is a transcription factor with a molecular mass of approximately 58 kDa. It contains zinc finger motifs which facilitate DNA binding and regulation of gene expression. ZNF404 predominantly localizes to the nucleus and scientists have observed its expression in various tissues including the brain liver and kidneys. These patterns suggest that ZNF404 could have several regulatory roles within these tissues.

Biological function summary

The modulation of gene expression by ZNF404 impacts cellular differentiation and development. Researchers have identified its involvement in forming transcriptional complexes allowing it to influence gene regulatory networks. By interacting with other proteins like co-repressors or co-activators ZNF404 fine-tunes the transcriptional activity important for maintaining cellular homeostasis.

Pathways

ZNF404 plays a role in the Wnt signaling pathway which is essential for cellular processes like proliferation and differentiation. In this context ZNF404 can interact with proteins such as β-catenin which is an important player in the pathway. Furthermore it is involved in chromatin remodeling affecting how genetic information is accessed and used by interacting with histone-modifying enzymes in the pathway.

ZNF404 has been implicated in cancer and neurodegenerative diseases. In cancer aberrant expression of ZNF404 may alter the regulation of oncogenes or tumor suppressor genes impacting tumor progression. Its interaction with proteins like p53 suggests a role in cellular stress responses relevant to tumorigenesis. Neurodegenerative diseases also show altered expression of ZNF404 possibly disrupting normal neuronal gene expression and contributing to disease pathology.