Recombinant Human ZNF43 protein is a Human Fragment protein, in the 39 to 294 aa range, expressed in Escherichia coli, with =90% purity and suitable for SDS-PAGE.
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
May be involved in transcriptional regulation.
KOX27, ZNF39, ZNF39L1, ZNF43, Zinc finger protein 43, Zinc finger protein 39, Zinc finger protein HTF6, Zinc finger protein KOX27
Recombinant Human ZNF43 protein is a Human Fragment protein, in the 39 to 294 aa range, expressed in Escherichia coli, with =90% purity and suitable for SDS-PAGE.
Constituents: 0.58% Sodium chloride, 0.32% Tris HCl
Purity determined to be 90% by SDS-PAGE.
May be involved in transcriptional regulation.
Belongs to the krueppel C2H2-type zinc-finger protein family.
ZNF43 also known as Zinc Finger Protein 43 is a transcription factor that binds to DNA and regulates gene expression. The protein mass is approximately 79 kDa. It is expressed in various tissues including the brain liver and kidney. As a zinc finger protein ZNF43 contains multiple zinc finger domains which are essential for its binding to specific DNA sequences.
Zinc finger proteins like ZNF43 function in regulating transcription of genes by binding to their promoter regions. ZNF43 may interact with other transcriptional regulators although it is not currently known to be a part of a larger complex. This interaction can affect several cellular processes such as growth and differentiation ensuring cells respond properly to different signals.
ZNF43 plays a role in the regulation of some signaling pathways including the MAPK and Wnt pathways. These pathways are critical in controlling cell proliferation and differentiation. ZNF43 may interact with other proteins within these pathways such as β-catenin which is central to the Wnt signaling pathway. Such interactions can lead to modulation of cell fate decisions and tissue homeostasis.
Dysfunction or aberrant expression of ZNF43 is associated with certain types of cancer including breast cancer. It is thought that misregulation of ZNF43 can lead to abnormal cell growth and cancer progression. Connections between ZNF43 and other proteins such as p53 in cancer contexts may affect tumor suppressive pathways compromising the cell’s ability to prevent malignancy.
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