Recombinant Human ZNF439 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF439 also known as zinc finger protein 439 functions as a transcription factor. This protein contains multiple C2H2 zinc finger domains which recognize and bind to specific DNA sequences to regulate gene expression. ZNF439 has a confirmed molecular mass of approximately 52 kDa. It is expressed in several tissues including the brain and liver where it exerts its functions by modulating the transcription of target genes critical for cellular processes.

Biological function summary

This zinc finger protein plays important roles in regulating cell proliferation and development. It forms interactions with other proteins and may act as part of a larger transcriptional complex. Through its DNA-binding capabilities ZNF439 influences the transcriptional landscape of the cell potentially affecting various cellular functions such as differentiation and response to external stimuli.

Pathways

The regulatory activities of ZNF439 connect it to significant cellular signaling pathways including the Wnt signaling pathway and cell cycle control pathway. In these pathways ZNF439 is associated with other key regulatory proteins like β-catenin and cyclins that modulate cellular processes like growth and division. By influencing these pathways ZNF439 may impact gene networks critical for maintaining normal cellular functions and responses.

Alterations in ZNF439 expression or function may contribute to the development of cancer and neurodegenerative diseases. Abnormal activity or mutations in ZNF439 can disrupt normal gene regulation leading to unregulated cell growth or impaired neural function. Furthermore in cancer it is thought to interact with oncoproteins such as p53 while in neurodegeneration its function may intersect with proteins like amyloid precursor protein potentially influencing disease progression and outcomes.