Recombinant Human ZNF581 protein is a Human Full Length protein, in the 1 to 197 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
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| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
May be involved in transcriptional regulation.
HSPC189, ZNF581, Zinc finger protein 581
Recombinant Human ZNF581 protein is a Human Full Length protein, in the 1 to 197 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
pH: 8
Constituents: 0.32% Tris HCl
ab169912 was expressed in E.coli as inclusion bodies. The final product was refolded and chromatographically purified.
May be involved in transcriptional regulation.
ZNF581 also known as Zinc Finger Protein 581 is a transcription factor characterized by the presence of zinc finger domains which facilitate the binding to DNA. It has a molecular mass of about 72 kDa. ZNF581 expresses in a variety of tissues including the brain liver and reproductive tissues suggesting it plays roles in both central and peripheral systems. Its expression in these tissues hints at its importance in cellular regulatory functions.
The function of ZNF581 involves modulation of gene expression impacting cell proliferation and differentiation. This protein acts as a part of transcriptional regulatory complexes influencing the transcription of its target genes directly. The modulation performed by ZNF581 is essential for maintaining normal cellular functions. While specific partners of these complexes are not entirely defined its interactions are assumed to affect a wide range of cellular activities.
ZNF581 has been implicated in the signaling pathways related to cellular growth and development. It plays roles in pathways such as the Wnt signaling pathway and the MAP kinase pathway which are central to cellular responses and functions. It relates to proteins like beta-catenin in the Wnt pathway and ERK in the MAP kinase pathway mediating biological outcomes through its regulatory influence on gene expression.
Dysregulation of ZNF581 may contribute to conditions such as cancer and neurodevelopmental disorders. Overexpression or mutations in ZNF581 could result in proliferative disorders due to its role in gene expression. In particular its interaction with proteins like p53 and beta-catenin suggests connections to tumorigenesis and developmental anomalies linking its expression levels and functional mutations directly to disease phenotypes.
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