Recombinant Human ZNF8 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF8 also known as Zinc Finger Protein 8 mechanically functions as a transcription factor with zinc finger motifs that facilitate binding to specific DNA sequences. The molecular mass of ZNF8 is approximately 69 kDa. This protein expresses in various tissues including the brain liver and heart indicating its involvement in several physiological processes. Its expression pattern suggests roles that might differ based on the tissue type contributing to its diverse functional capabilities.

Biological function summary

ZNF8 plays a role in modulating gene expression by interacting with DNA and possibly regulating sets of target genes. While it may not be an obligatory part of a well-defined complex ZNF8 can influence the transcriptional machinery potentially affecting broad cellular processes like development and differentiation. By binding to promoters or enhancers ZNF8 regulates genes-critical in cellular identity maintenance and offers specificity to gene expression patterns across different cell types.

Pathways

ZNF8 influences pathways controlling cellular growth and differentiation offering regulatory input that affects cellular responses to developmental signals. It participates in the Wnt signaling pathway which is important in cell fate determination. In this capacity it may interact with other proteins such as β-catenin which is a central player in the Wnt pathway. The interplay between ZNF8 and these pathways emphasizes its regulatory impact on cell proliferation and stem cell maintenance.

ZNF8 shows associations with certain cancers and neurodevelopmental disorders. Aberrant expression or mutations within the ZNF8 gene may contribute to tumorigenesis potentially linked with other proteins like p53 which has a critical role in cell cycle regulation. Additionally altered ZNF8 function influences outcomes in neurological contexts potentially resulting in developmental disorders linked to disrupted gene expression patterns. Understanding these connections helps to evaluate therapeutic targets within these diseases.