Recombinant Human ZNF98 protein (His-DHFR tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF98 also known as zinc finger protein 98 functions as a transcription factor that binds to DNA through its zinc finger domains. These domains facilitate the regulation of gene expression by recognizing specific DNA sequences. ZNF98 has a molecular mass of approximately 73 kDa. This protein is expressed mainly in the nucleus of human cells with a notable presence in reproductive tissues such as the testis. ZNF98 can influence various genes affecting different cellular processes.

Biological function summary

The activity of ZNF98 influences the transcriptional regulation of target genes involved in cellular differentiation and development. ZNF98 acts as part of a complex that includes other zinc finger proteins working together to regulate DNA transcription. The accurate functioning of these complexes is important for maintaining the normal progression of cell growth and differentiation. ZNF98 may also impact chromatin remodeling further affecting gene accessibility and expression patterns.

Pathways

ZNF98 participates in key regulatory pathways related to gene expression modulation. It associates with the Notch signaling pathway which affects cell fate decisions during developmental processes. Additionally ZNF98 interacts with proteins in the Wnt signaling pathway linking it to cellular communication and the regulation of beta-catenin levels. These interactions illustrate the interconnected role of ZNF98 with other proteins enhancing the dynamic control of gene transcription.

Abnormalities in ZNF98 function may contribute to certain types of cancer such as testicular cancer. Dysregulation of ZNF98 might alter gene expression leading to uncontrolled cell proliferation. Additionally there is a potential link between ZNF98 and disorders involving developmental defects where aberrant expression could interfere with proper tissue formation. Similar effects are seen with other zinc finger proteins associated with cancer-related pathways emphasizing the significance of maintaining the normal expression levels of ZNF98.