Recombinant Human ZNHIT3 protein (denatured) (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNHIT3 also known as Zinc Finger HIT-Type Containing 3 acts as a protein involved in several cellular processes. The protein has a mass of approximately 29 kDa. ZNHIT3 is expressed in various tissues but shows higher levels in the brain and testis. Mechanically it interacts with other proteins through its zinc finger domains. These domains assist in binding molecular partners facilitating various cellular functions and interactions.

Biological function summary

ZNHIT3 functions as a critical component of several cellular complexes including the chromatin remodeling complexes. These complexes modulate the structure of chromatin thereby regulating gene expression. ZNHIT3 contributes to the maintenance of chromatin state impacting transcriptional activity. Its interaction with other proteins in these complexes highlights its role in gene regulatory mechanisms. Due to its involvement in chromatin dynamics ZNHIT3 is essential in managing both normal cellular proliferation and differentiation.

Pathways

ZNHIT3 participates in pathways related to chromosomal architecture and gene expression regulation including the chromatin modification and transcription regulation pathways. It associates with notable proteins such as BRG1 and SMARCA4 within these pathways. These interactions facilitate remodeling of nucleosome structures influencing accessibility to transcription factors and transcription machinery ensuring proper expression of genetic information.

ZNHIT3 has a link to several neurological disorders and cancer. Abnormal expression or mutations of ZNHIT3 relate to neurodevelopmental disorders as it plays a role in brain-specific gene expression. Additionally ZNHIT3 connects with cancer-related proteins like BRD4 indicating its potential involvement in tumorigenesis. Further comprehension of ZNHIT3's function and regulation could provide insights into its contribution to these diseases highlighting its importance in therapeutic research.