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AB124562

Recombinant Influenza A H3 (H3N2) protein

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(1 Publication)

Recombinant Influenza A H3 (H3N2) protein is a Fragment protein, in the 18 to 344 aa range, expressed in Baculovirus infected BTI-TN-5B1-4 cells, with >90%, suitable for SDS-PAGE.
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SDS-PAGE - Recombinant Influenza A H3 (H3N2) protein (AB124562)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Influenza A H3 (H3N2) protein (AB124562)

ab124562 (3μg) visualised by SDS-PAGE (15%).

Key facts

Purity

>90% SDS-PAGE

Expression system

Baculovirus infected BTI-TN-5B1-4 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Animal free

No

Carrier free

No

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"ADNLPGNENNAATLCLGHHAVPNGTIVKTITDDQIEVTNATELVQNSSTGKICNNPHKILDGRDCTLIDALLGDPHCDVFQNETWDLFVERSNAFSNCYPYDVPDYASLRSIVASSGTLEFITEGFTWAGVTQNGGSGACKKGPANGFFSRLNWLTKSGNTYPVLNVTMPNNNNFDKLYIWGVHHPSTNQEQTSLYIQASGRVKVSTRRSQQTIIPNIGSRPLVRGQSGRISVYWTIVKPGDVLVINSNGNLIAPRGYFKMRIGKSSIMRSDAPIDTCISECITPNGSIPNEKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPERQTHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"36.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":344,"aminoAcidStart":18,"nature":"Recombinant","expressionSystem":"Baculovirus infected BTI-TN-5B1-4 cells","accessionNumber":null,"tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

H3 (H3N2) also known as A/H3 influenza is an influenza A virus subtype. This target plays a mechanical role in the virus's entry into host cells. The hemagglutinin protein or HA which has a mass of approximately 84 kDa is expressed on the surface of the virus. HA binds to sialic acid receptors on host cell surfaces facilitating viral entry. Researchers often study this process to understand its structural adaptations and responses to immune pressures.
Biological function summary

The H3 influenza A subtype contributes to the seasonal influenza epidemics observed globally. Within the viral envelope HA acts alongside neuraminidase (NA) as part of the functional machinery required for viral replication and release from host cells. The HA a trimeric protein complex undergoes conformational changes which are critical to the virus infectivity and host range adaptation.

Pathways

The influenza A virus including the H3N2 subtype integrates into the host cell endocytic pathway upon cell entry. This viral host engagement is mediated by the HA protein interaction with cellular pathways that facilitate vesicular trafficking. During the virus life cycle the interaction between HA and the host immune response pathway is significant involving proteins such as M2 ion channel which helps in viral uncoating.

H3N2 influenza is a major cause of seasonal flu pandemics characterized by respiratory illness with varying severity. The HA protein within the H3N2 subtype plays an important role in vaccine design due to its antigenic properties. It is closely linked with neuraminidase in disease propagation making it a target for neuraminidase inhibitors used in treatment. Researchers aim to understand how structural variations in HA contribute to immune escape and vaccine efficacy.
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Specifications

Form

Liquid

Additional notes

Affinity purified

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General info

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Product protocols

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Target data

See full target information H3 (H3N2)

Additional targets

H3 (H3N2)
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Clinical and experimental vaccine research 8:124-131 PubMed31406694

2019

Transient expression of hemagglutinin antigen from canine influenza virus H3N2 in and .

Applications

Unspecified application

Species

Unspecified reactive species

Puna Maya Maharjan,Sunghwa Choe
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