Recombinant Influenza A Influenza A Virus M2 Protein is a Full Length protein, in the 1 to 97 aa range, expressed in Cell free, with >=85% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >=85% SDS-PAGE
- Expression system
- Cell free
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M S L L T E V E T P T R S G W E C R C S D S S D P L V I A A N I I G I L H L I L W I T D R L F F K C I Y R R F K Y G L K R G P S T E G V P E S M R E E Y Q Q E Q Q S A V D V D D G H F V N I E L E
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Alternative names
Influenza A virus matrix protein M2, Matrix protein 2, Membrane ion channel M2, Membrane protein M2, Proton channel protein M2
Recommended products
Recombinant Influenza A Influenza A Virus M2 Protein is a Full Length protein, in the 1 to 97 aa range, expressed in Cell free, with >=85% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >=85% SDS-PAGE
- Expression system
- Cell free
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Animal free
- Yes
- Concentration
- Storage buffer
pH: 7.4 - 8
Constituents: 6% Trehalose, 0.12% Tris, 0.037% Ethylenediaminetetraacetic acid, disodium, dihydrate
Sequence info
Amino acid sequence
- M S L L T E V E T P T R S G W E C R C S D S S D P L V I A A N I I G I L H L I L W I T D R L F F K C I Y R R F K Y G L K R G P S T E G V P E S M R E E Y Q Q E Q Q S A V D V D D G H F V N I E L E
- Protein length
- Full Length
- Predicted molecular weight
- 18.6 kDa
- Amino acids
- 1 to 97
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Lyophilized
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The Influenza A Virus M2 Protein also known as M2 ion channel or matrix protein 2 plays an essential role in the viral life cycle. This protein has a mass of approximately 97 amino acids and is expressed on the envelope of the Influenza A virus. It functions as a proton-selective channel facilitating the acidification of the viral interior after the virus enters the host cell. This acidification process is important for the uncoating of the viral genome allowing subsequent replication of the virus in host cells.
- Biological function summary
The M2 protein from Influenza A virus participates in virus assembly budding and release. The protein operates as a tetramer creating a channel across the viral membrane. This channel is essential for the correct function and structure of the virus playing an important role in membrane fusion and release of the viral particles. It often works in conjunction with another matrix protein M1 which assists in stabilizing the integrity of the viral structure.
- Pathways
The M2 Influenza protein is integral to the viral replication and assembly pathway. It aligns with the function of the viral ribonucleoprotein complex and is significant in the viral entry and exit pathways. Additionally the connection to the M1 matrix protein highlights its coordinated role in facilitating the assembly and release of new virions from the infected cells emphasizing its necessity in productive viral replication.
- Associated diseases and disorders
The Influenza A virus M2 protein is directly related to the pathogenesis of seasonal influenza. Antiviral drugs like amantadine and rimantadine target this ion channel to disrupt viral replication. Resistance mutations in the M2 protein can influence the efficacy of these drugs impacting treatment outcomes. There is also a link with immune system responses where M2 interactions with other viral proteins can modulate host immune evasion mechanisms.
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1 product image
SDS-PAGE - Recombinant Influenza A Influenza A Virus M2 Protein (ab289763)
SDS-PAGE analysis of ab289763
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