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AB225599

Recombinant Influenza B Virus Nucleoprotein (Tagged)

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Recombinant Influenza B Virus Nucleoprotein (Tagged) is a Full Length protein, in the 1 to 560 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.
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SDS-PAGE - Recombinant Influenza B Virus Nucleoprotein (Tagged) (AB225599)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Influenza B Virus Nucleoprotein (Tagged) (AB225599)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis of ab225599 with 5% enrichment gel and 15% separation gel.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

6x His tag N-Terminus SUMO tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Animal free

No

Carrier free

No

Storage buffer

Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Secondary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSNMDIDGINTGTIDKTPEEIISGTSGATRPIIRPATLAPPSNKRTRNPSPERATTSSEADVGRKTQKKQTPTEIKKSVYNMVVKLGEFYNQMMVKAGLNDDMERNLIQNAHAVERILLAATDDKKTEFQKKKNARDVKEGKEEIDHNKTGGTFYKMVRDDKTIYFSPIRITFLKEEVKTMYKTTMGSDGFSGLNHIMIGHSQMNDVCFQRSKALKRVGLDPSLISTFAGSTLPRRSGATGVAIKGGGTLVAEAIRFIGRAMADRGLLRDIKAKTAYEKILLNLKNKCSAPQQKALVDQVIGSRNPGIADIEDLTLLARSMVVVRPSVASKVVLPISIYAKIPQLGFNVEEYSMVGYEAMALYNMATPVSILRMGDDAKDKSQLFFMSCFGAAYEDLRVLSALTGTEFKPRSALKCKGFHVPAKEQVEGMGAALMSIKLQFWAPMTRSGGNEVGGDGGSGQISCSPVFAVERPIALSKQAVRRMLSMNIEGRDADVKGNLLKMMNDSMAKKTNGNAFIGKKMFQISDKNKTNPVEIPIKQTIPNFFFGRDTAEDYDDLDY","proteinLength":"Full Length","predictedMolecularWeight":"77.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":560,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":null,"tags":[{"tag":"6x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Influenza B Virus Nucleoprotein often known as NP or flu B NP is an essential structural protein with a molecular weight of approximately 56 kDa. It plays a role in the influenza B virus lifecycle by encapsidating the viral RNA forming the ribonucleoprotein complex important for viral replication and transcription. This protein expresses in the host cell's cytoplasm and nucleus facilitating the export of vRNPs from the nucleus.
Biological function summary

The ribonucleoprotein complex formation involves nucleoproteins assembling with the viral RNA and polymerase subunits securing the genome for replication and transcription. NP interacts with both the polymerase basic 2 (PB2) and polymerase acidic (PA) proteins forming a vital part of the complex. This interaction allows the viral RNA to maintain its structure and function effectively during the virus infection cycle aiding both Influenza A and B viruses.

Pathways

NP participates in the viral replication pathway supporting the influenza virus propagation in infected cells. It associates closely with viral RNA polymerases and is integral to the transcription and replication of the viral RNA genome. Other key proteins involved in these pathways include the polymerase basic 1 (PB1) protein essential for synthesizing viral mRNA and the matrix protein (M1) which aids in vRNA encapsidation and budding.

NP relates closely to influenza B infections contributing to the clinical symptoms of flu B such as fever and respiratory issues. This protein is also a potential target for vaccine and therapeutic development against influenza B. NP shares a connection with the M2 protein another target in antiviral strategies given its role in proton channel activity and viral uncoating. Understanding NP's role can guide the creation of flu B antibodies and influenza A and B antibodies to reduce disease severity or prevent flu infections.
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Specifications

Form

Liquid

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General info

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Product protocols

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Target data

See full target information Influenza B Virus Nucleoprotein

Additional targets

Influenza B Virus Nucleoprotein
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