Recombinant JCV Polyomavirus Major Capsid VP1 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The JCV-VP1 protein allows the JC virus to infect and replicate within human host cells. It forms a principal component of the viral capsid allowing the virus to protect its genetic material from the environment. This protein interacts with cell surface receptors on host cells which is important for the viral entry process. While VP1 is singularly integral to the capsid it operates alongside other proteins like VP2 and VP3 within the virus particle.

Pathways

The JCV-VP1 protein leverages host cellular pathways to support viral replication and spread. It ties into the endocytic pathway important for viral entry and interacts with major histocompatibility complex class I molecules like HLA-A*02:01. VP1 may engage with proteins involved in these pathways facilitating viral entry and consequent propagation within the host.