Recombinant kgp protein (Tagged)
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(1 Publication)
Recombinant kgp protein (Tagged) is a Porphyromonas gingivalis ATCC 33277 Fragment protein, in the 229 to 594 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
PGN_1728, kgp, Lys-gingipain, Lysine-specific cysteine proteinase Kgp
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant kgp protein (Tagged) (AB238238)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab238238 could indicate that this peptide derived from E.coli-expressed Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) kgp.
- Mass Spec
Unknown
Mass Spectrometry - Recombinant kgp protein (Tagged) (AB238238)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab238238 could indicate that this peptide derived from E.coli-expressed Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) kgp.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant kgp protein (Tagged) (AB238238)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab238238.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Lysine gingipain contributes to the pathogenicity of Porphyromonas gingivalis by degrading host proteins and evading immune responses. It is an important component of the protein complex associated with the bacterium's ability to colonize and persist in the host's tissues. Kgp activity modulates interactions with the host facilitating bacterial adherence and invasion into tissues. Consequently it plays a significant role in the bacterium's capability to sustain infection and cause damage to the host's immune system.
Pathways
The involvement of lysine gingipain is important in pathways related to inflammatory response and immune evasion. The enzyme interacts with complement proteins and influences the kallikrein-kinin system. Additionally it relates functionally with proteins like gingipain R both involved in processing extracellular matrix components which furthers the pathogenic mechanisms of Porphyromonas gingivalis. This protease's activity influences critical host-pathogen interactions that drive inflammation and tissue destruction.
Specifications
Form
Liquid
General info
Function
Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria.
Sequence similarities
Belongs to the peptidase C25 family.
Post-translational modifications
Proteolytically cleaved into a catalytic subunit and three adhesins. Arg-gingipain is involved in this post-translational processing (By similarity).
Target data
Publications (1)
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Oxidative medicine and cellular longevity 2022:5265616 PubMed36035217
2022
Applications
Unspecified application
Species
Unspecified reactive species
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