Recombinant Leishmania donovani KMP-11 protein is a Leishmania donovani Full Length protein, in the 1 to 92 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, WB, Dot, ELISA.
M A T T Y E E F S A K L D R L D Q E F N R K M Q E Q N A K F F A D K P D E S T L S P E M R E H Y E K F E R M I K E H T E K F N K K M H E H S E H F K Q K F A E L L E Q Q K A A Q Y P S K
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Application Dot | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info 0.60000-1.70000 µg/mL | Notes - |
May be involved in the regulation of the cytoskeleton through interaction with the subpellicular microtubules. May be involved in parasite mobility and attachment to the surface of the host cell. Strongly stimulates T-cell proliferation and is thought to play a role in the immunology of leishmaniasis.
KMP11
Kinetoplastid membrane protein 11, KMP-11, Lipophosphoglycan-associated protein, LPGAP
Recombinant Leishmania donovani KMP-11 protein is a Leishmania donovani Full Length protein, in the 1 to 92 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, WB, Dot, ELISA.
Preservative: 1.7% Imidazole
Constituents: 97% Phosphate Buffer, 0.6% Sodium chloride, 0.1% Poly(oxy-1,2-ethanediyl), .alpha.-tridecyl-.omega.-hydroxy-
May be involved in the regulation of the cytoskeleton through interaction with the subpellicular microtubules. May be involved in parasite mobility and attachment to the surface of the host cell. Strongly stimulates T-cell proliferation and is thought to play a role in the immunology of leishmaniasis.
Belongs to the KMP-11 family.
A minor in vivo processed fragment (IVP) also exists, probably as a result of proteolysis.
Kinetoplastid membrane protein 11 (KMP11) also known as KMP-11 is a small protein with a molecular mass of approximately 11 kDa. It is mainly expressed on the surface of kinetoplastids a group of protozoans such as Leishmania and Trypanosoma. The protein shows highly conserved sequences across different species within this group indicating its significance in these organisms.
KMP11 plays a role in the structural integrity and viability of the parasite. KMP11 is likely involved in signal transduction and cellular adhesion aiding the parasite's survival and propagation within host organisms. While not part of a known complex its interaction with other surface molecules enables it to perform these roles effectively.
KMP11 interacts within the broader context of parasitic survival and host-pathogen interaction mechanisms. It aligns with the cellular adhesion and signaling pathways allowing effective parasitic invasion and immune system evasion. Proteins such as GP63 and LPG are related through these pathways contributing to the pathogen's lifecycle and infective capacity.
KMP11 is linked to parasitic infections like leishmaniasis and Chagas disease. These conditions are often caused by Leishmania and Trypanosoma species respectively. KMP11 connects with protein LPG in these diseases as both play roles in immune evasion strategies making them targets for disease intervention strategies and vaccine development efforts.
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