Recombinant Leptospira interrogans Leptospira interrogans LipL32 protein (Tagged-His Tag)

Supplementary information

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Leptospira interrogans LipL32 also known as Lipoprotein L32 is a major outer membrane lipoprotein of the Leptospira bacterium involved in the pathogenicity of leptospirosis. With a molecular mass of approximately 32 kDa LipL32 is primarily expressed on the surface of pathogenic Leptospira strains. It is one of the most abundant proteins in this organism making up to 75% of the total membrane protein composition. This lipoprotein is not found in non-pathogenic or saprophytic species of Leptospira.

Biological function summary

LipL32 plays an important role in the interaction between the pathogen and its host. It participates in host tissue-damage and immune evasion facilitating bacterial survival and proliferation inside the host. LipL32 binds to extracellular matrix proteins like laminin and fibronectin helping the bacterium adhere to and invade host tissues. It is not a part of a larger protein complex but functions independently to exert its effects.

Pathways

LipL32 is involved in the adherence and invasion pathway of Leptospira enhancing the ability of the pathogen to penetrate the host's epithelial barrier. This function relates to proteins involved in the extracellular matrix interaction pathway such as laminin-binding proteins and fibronectin-binding proteins. By promoting strong interactions with these proteins LipL32 enhances the successful colonization of host tissues.

LipL32 is a significant factor in the development of leptospirosis a zoonotic disease affecting humans and animals. This lipoprotein contributes to the disease's clinical manifestations like jaundice and renal dysfunction. It has also been associated with severe respiratory manifestations in leptospirosis cases. LipL32 can interact with immune modulating factors potentially impacting the progression of the infection. Through its pathogen-host interaction LipL32 presents as a target for research into therapeutic interventions for leptospirosis.