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AB225960

Recombinant Major pollen allergen Lol p 5a protein (Tagged)

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Recombinant Major pollen allergen Lol p 5a protein (Tagged) is a Lolium perenne Full Length protein, in the 26 to 307 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

Major pollen allergen Lol p 5a, Allergen Lol p Ib, Allergen Lol p Va, LOLPIB

1 Images
SDS-PAGE - Recombinant Major pollen allergen Lol p 5a protein (Tagged) (AB225960)
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Supplier Data

SDS-PAGE - Recombinant Major pollen allergen Lol p 5a protein (Tagged) (AB225960)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis of ab225960 with 5% enrichment gel and 15% separation gel.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

10x His tag N-Terminus SUMO tag N-Terminus Myc tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q40240

Animal free

No

Carrier free

No

Species

Lolium perenne

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"ADAGYTPAAAATPATPAATPAAAGGKATTDEQKLLEDVNAGFKAAVAAAANAPPADKFKIFEAAFSESSKGLLATSAAKAPGLIPKLDTAYDVAYKAAEATPEAKYDAFVTALTEALRVIAGALEVHAVKPATEEVLAAKIPTGELQIVDKIDAAFKIAATAANAAPTNDKFTVFESAFNKALNECTGGAYETYKFIPSLEAAVKQAYAATVAAAPEVKYAVFEAALTKAITAMTQAQKAGKPAAAAATAAATVATAAATAAAVLPPPLLVVQSLISLLIYY","proteinLength":"Full Length","predictedMolecularWeight":"48.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":307,"aminoAcidStart":26,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q40240","tags":[{"tag":"10x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"},{"tag":"Myc","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The major pollen allergen Lol p 5a also known as Lolium perenne group 5 allergen is a significant protein found in ryegrass pollen. This protein weighs around 28 kDa and is widely expressed in the pollen of the perennial ryegrass a common allergenic plant. It plays a mechanical role in pollen grain wall integrity and pollen-tube growth contributing to the reproductive success of the plant. Its strong allergenic properties make it key for immune responses in individuals sensitive to grass pollen.
Biological function summary

This allergen elicits strong immune responses in humans often leading to allergic reactions. It forms a part of a complex network of pollen proteins that trigger the body's defense mechanisms. This interaction is key in conditioning the immune system's recognition and response to non-self proteins from the pollen often causing hay fever or allergic rhinitis symptoms in many individuals. As one of the major protein components in pollen its presence is felt prominently during grass pollination seasons.

Pathways

The immune response pathway primarily involves IgE-mediated reactions. Lol p 5a interacts with immune cells such as mast cells and basophils. It stands out in the adaptive immune pathway where these immune cells release histamines and other mediators upon activation. Other pollen proteins might compete for IgE but Lol p 5a often remains the dominant allergen prompting more targeted immune reactions.

Lol p 5a plays a notable role in allergies like hay fever and asthma conditions significantly affecting respiratory health. The allergen's interaction with immune proteins such as IgE leads to hypersensitivity reactions characterized by inflammation and nasal congestion. Its link with other pollen-derived allergenic proteins further compounds these allergic responses contributing to persistent symptoms in sensitive individuals.
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Specifications

Form

Liquid

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General info

Sequence similarities

Belongs to the Poa p IX/Phl p VI allergen family.

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Product protocols

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Target data

See full target information LOLPIB
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