Recombinant Mouse 4-1BBL protein (His tag) is a Mouse Fragment protein, in the 104 to 309 aa range, expressed in HEK 293, with >=90% purity and suitable for SDS-PAGE, WB.
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Key facts
- Purity
- >=90% SDS-PAGE
- Expression system
- HEK 293 cells
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, WB
- Biologically active
- No
Amino acid sequence
R T E P R P A L T I T T S P N L G T R E N N A D Q V T P V S H I G C P N T T Q Q G S P V F A K L L A K N Q A S L C N T T L N W H S Q D G A G S S Y L S Q G L R Y E E D K K E L V V D S P G L Y Y V F L E L K L S P T F T N T G H K V Q G W V S L V L Q A K P Q V D D F D N L A L T V E L F P C S M E N K L V D R S W S Q L L L L K A G H R L S V G L R A Y L H G A Q D A Y R D W E L S Y P N T T S F G L F L V K P D N P W E
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
Alternative names
Cd137l, Cd157l, Ly63l, Tnfsf9, Tumor necrosis factor ligand superfamily member 9, 4-1BB ligand, 4-1BBL
Recommended products
Recombinant Mouse 4-1BBL protein (His tag) is a Mouse Fragment protein, in the 104 to 309 aa range, expressed in HEK 293, with >=90% purity and suitable for SDS-PAGE, WB.
Key facts
- Purity
- >=90% SDS-PAGE
- Expression system
- HEK 293 cells
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, WB
- Biologically active
- No
- Accession
- P41274-1
- Animal free
- No
- Species
- Mouse
- Concentration
- Storage buffer
pH: 7.4
Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.13% Sodium phosphate, 0.02% Potassium chloride
Sequence info
Amino acid sequence
- R T E P R P A L T I T T S P N L G T R E N N A D Q V T P V S H I G C P N T T Q Q G S P V F A K L L A K N Q A S L C N T T L N W H S Q D G A G S S Y L S Q G L R Y E E D K K E L V V D S P G L Y Y V F L E L K L S P T F T N T G H K V Q G W V S L V L Q A K P Q V D D F D N L A L T V E L F P C S M E N K L V D R S W S Q L L L L K A G H R L S V G L R A Y L H G A Q D A Y R D W E L S Y P N T T S F G L F L V K P D N P W E
- Accession
- P41274
- Protein length
- Fragment
- Predicted molecular weight
- 26 kDa
- Amino acids
- 104 to 309
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
- Sequence similarities
Belongs to the tumor necrosis factor family.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The 4-1BBL protein also known as CD137L or 4-1BB ligand acts mechanically as a member of the tumor necrosis factor (TNF) superfamily. The 4-1BBL with a mass of around 36 kDa exists as a type II transmembrane protein. It gets expressed on activated antigen-presenting cells like dendritic cells macrophages and B cells. This costimulatory molecule primarily interacts with its receptor 4-1BB (CD137) on T cells promoting their activation.
- Biological function summary
The 4-1BBL protein plays an important role in mediating the co-stimulatory signal needed for T-cell proliferation survival and cytokine production. This protein contributes to the formation of the immunological synapse and doesn't exist alone but rather interacts directly with its receptor CD137 forming a receptor-ligand complex. The 4-1BBL-CD137 interaction strengthens signals delivered by the T-cell receptor enhancing immune responses.
- Pathways
The 4-1BBL protein integrates into immune-related signaling pathways. It significantly impacts the NF-kB and MAPK pathways important for T cell survival and activation. The interaction between 4-1BBL and its related proteins such as the 4-1BB/CD137 receptor initiates downstream cascades that lead to the activation of transcription factors involved in immune response.
- Associated diseases and disorders
The 4-1BBL protein connects to conditions such as cancer and autoimmune diseases. Overexpression or dysregulation of 4-1BBL has associations with autoimmune conditions like rheumatoid arthritis due to prolonged T cell activation. In cancer 4-1BBL's interaction with CD137 has potential therapeutic implications with efforts to harness this axis to bolster anti-tumor immunity. The modulation of 4-1BBL activity can influence disease outcomes highlighting its significance as a target for therapeutic interventions.
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1 product image
SDS-PAGE - Recombinant Mouse 4-1BBL protein (His tag) (ab271407)
SDS-PAGE analysis of ab271407.
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