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AB225975

Recombinant Mouse AE binding protein 1 (His tag)

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Recombinant Mouse AE binding protein 1 (His tag) is a Mouse Fragment protein, in the 26 to 370 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Aclp, Aebp1, Adipocyte enhancer-binding protein 1, AE-binding protein 1, Aortic carboxypeptidase-like protein

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Mass Spectrometry - Recombinant Mouse AE binding protein 1 (His tag) (AB225975)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Mouse AE binding protein 1 (His tag) (AB225975)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS analysis result of ab225975 could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) AE binding protein 1.

Mass Spectrometry - Recombinant Mouse AE binding protein 1 (His tag) (AB225975)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Mouse AE binding protein 1 (His tag) (AB225975)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS analysis result of ab225975 could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) AE binding protein 1.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q640N1

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"QTVLTDDEIEEFLEGFLSELETQSPPREDDVEVQPLPEPTQRPRKSKAGGKQRADVEVPPEKNKDKEKKGKKDKGPKATKPLEGSTRPTKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKRPSAGKKFSTVAPLETLDRLLPSPSNPSAQELPQKRDTPFPNAWQGQGEETQVEAKQPRPEPEEETEMPTLDYNDQIEKEDYEDFEYIRRQKQPRPTPSRRRLWPERPEEKTEEPEERKEVEPPLKPLLPPDYGDSYVIPNYDDLDYYFPHPPPQKPDVGQEVDEEKEEMKKPKKEGSSPKEDTEDKWTVEKNKDHKGPRKGEELEEEWAP","proteinLength":"Fragment","predictedMolecularWeight":"55.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":370,"aminoAcidStart":26,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q640N1","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AE binding protein 1 also known as AEBP1 functions mechanically as a transcriptional repressor. It interacts with other proteins to alter gene expression. The protein has a molecular mass of approximately 150 kDa. Researchers find AEBP1 in various tissues but expression is high in adipose tissue and the uterus. The protein's role as a repressor links to its ability to modulate the activities of certain transcription factors influencing cellular processes.
Biological function summary

AEBP1 plays a role in regulating the expression of genes important for adipogenesis and inflammation. It acts as part of a transcriptional regulation complex that controls genes driving fat cell development and lipid metabolism. Beyond adipose tissue AEBP1 also influences inflammatory responses which may connect to its function in modulating the immune system. The protein's ability to interact with intracellular pathways points to its involvement in cellular functions critical for maintaining homeostasis.

Pathways

AEBP1 integrates into the PPARγ signaling pathway. This pathway is important for adipocyte differentiation and lipid homeostasis. AEBP1's interaction with PPARγ connects it to the regulation of adipogenesis and metabolism. AEBP1 also participates indirectly in pathways modulating inflammatory responses. Through these connections AEBP1 influences proteins like C/EBPα which are key regulators of adipocyte commitment and growth.

AEBP1 has associations with obesity and inflammatory disorders. Its role in adipogenesis and inflammation links AEBP1 to obesity-related conditions where altered expression may contribute to weight gain and metabolic imbalances. Inflammatory disorders also involve AEBP1 as its modulation of immune-related factors can exacerbate or mitigate inflammation. Researchers recognize connections between AEBP1 and other proteins involved in these diseases such as NF-κB where AEBP1's regulation of inflammatory pathways could impact the progression of inflammatory diseases.
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Specifications

Form

Liquid

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General info

Function

Isoform 1. As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix.. Isoform 2. May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.

Sequence similarities

Belongs to the peptidase M14 family.

Post-translational modifications

Phosphorylated by MAPK1 in vitro.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Isoform 1. As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix.. Isoform 2. May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.
See full target information Aebp1
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