Recombinant mouse AL-1 protein (His tag)
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Recombinant mouse AL-1 protein (His tag) is a Mouse Fragment protein, in the 1 to 203 aa range, expressed in HEK 293 cells, with >97%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.
View Alternative Names
Epl7, Eplg7, Lerk7, Efna5, Ephrin-A5, AL-1, EPH-related receptor tyrosine kinase ligand 7, LERK-7
- FuncS
Supplier Data
Functional Studies - Recombinant mouse AL-1 protein (His tag) (AB276882)
Measured by its binding ability in a functional ELISA.
Immobilized Mouse EPHA5 at 2 μg/ml (100 μl/well) can bind mouse EFNA4 with a linear ranger of 1.28-32 ng/ml.
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant mouse AL-1 protein (His tag) (AB276882)
SDS-PAGE analysis of ab276882
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The protein acts as a modulator in both innate and adaptive immune systems helping in the resolution of inflammation. AL-1 may function as part of a complex in these processes interacting with receptors on the cell surface. This protein regulates actions including cell migration and apoptotic cell clearance directly impacting how the body responds to infection and inflammation.
Pathways
AL-1 influences key immunological processes via the phospholipase A2-inhibitory pathway. It can interact with proteins like S100A11 playing an important role in feedback mechanisms that control inflammation levels. AL-1 also interfaces with the annexin pathway which is important for modulating cell membrane interactions during immune responses.
Specifications
Form
Lyophilized
General info
Function
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.
Sequence similarities
Belongs to the ephrin family.
Target data
Complementary Products
Product promise
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