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AB235617

Recombinant Mouse AMH protein

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Recombinant Mouse AMH protein is a Mouse Fragment protein, in the 450 to 552 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Muellerian-inhibiting factor, Anti-Muellerian hormone, Muellerian-inhibiting substance, AMH, MIS, Amh

3 Images
Mass Spectrometry - Recombinant Mouse AMH protein (AB235617)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Mouse AMH protein (AB235617)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab235617 indicates that this peptide derived from E.coli-expressed Mus musculus (Mouse) Amh.

Mass Spectrometry - Recombinant Mouse AMH protein (AB235617)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Mouse AMH protein (AB235617)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab235617 indicates that this peptide derived from E.coli-expressed Mus musculus (Mouse) Amh.

SDS-PAGE - Recombinant Mouse AMH protein (AB235617)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse AMH protein (AB235617)

ab235617 analyzed by (Tris-Glycine gel) discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

P27106

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"DKGQDGPCALRELSVDLRAERSVLIPETYQANNCQGACRWPQSDRNPRYGNHVVLLLKMQARGAALGRLPCCVPTAYAGKLLISLSEERISADHVPNMVATEC","proteinLength":"Fragment","predictedMolecularWeight":"11.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":552,"aminoAcidStart":450,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P27106","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

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General info

Function

Plays an important role in several reproductive functions, including Muellerian duct regression during male fetal sexua,l differentiation and in the adult plays a role in Leydig cell differentiation and function (PubMed : 1782869, PubMed : 9435237). In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (PubMed : 11606457, PubMed : 11861535). Binds to its sole type II receptor, AMHR2 that recruits type I receptors ACVR1 and BMPR1A which subsequently activates the Smad pathway (By similarity).

Sequence similarities

Belongs to the TGF-beta family.

Post-translational modifications

Preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active non-covalent complex. Binding of the non-covalent complex to AMHRII induces dissociation of the pro-region from the mature C-terminal dimer. The N-terminal portion of the protein, despite having no intrinsic activity, has the role of amplifying the activity of the C-terminus.

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Product protocols

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Target data

Plays an important role in several reproductive functions, including Muellerian duct regression during male fetal sexua,l differentiation and in the adult plays a role in Leydig cell differentiation and function (PubMed : 1782869, PubMed : 9435237). In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (PubMed : 11606457, PubMed : 11861535). Binds to its sole type II receptor, AMHR2 that recruits type I receptors ACVR1 and BMPR1A which subsequently activates the Smad pathway (By similarity).
See full target information Amh
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