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AB276975

Recombinant Mouse ART4/DOK1 protein (His tag)

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Recombinant Mouse ART4/DOK1 protein (His tag) is a Mouse Fragment protein, in the 1 to 263 aa range, expressed in HEK 293 cells, with >92%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

CD297, Ecto-ADP-ribosyltransferase 4, ADP-ribosyltransferase C2 and C3 toxin-like 4, Mono(ADP-ribosyl)transferase 4, NAD(P)(+)--arginine ADP-ribosyltransferase 4, ARTC4, Art4

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SDS-PAGE - Recombinant Mouse ART4/DOK1 protein (His tag) (AB276975)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse ART4/DOK1 protein (His tag) (AB276975)

SDS-PAGE analysis of ab276975

Key facts

Purity

>92% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9CRA0

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

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Anti-E2 tag antibody [5E11]

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"MALWLPGGQLTLLLLLWVQQTPAGSTEAPLKVDVDLTPNSFDDQYQGCSEQMVEELNQGDYFIKEVDTHKYYSRAWQKAHLTWLNQAKALPESMTPVHAVAIVVFTLNLNVSSDLAKAMARAAGSPGQYSQSFHFKYLHYYLTSAIQLLRKDSSTKNGSLCYKVYHGMKDVSIEANVGSTIRFGQFLSASLLKEETRVSGNQTLFTIFTCLGASVQDFSLRKEVLIPPYELFEVVSKSGSPKGDLINLRSAGNMSTYNCQLLK","proteinLength":"Fragment","predictedMolecularWeight":"28.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":263,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9CRA0","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Form
Lyophilized
Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ART4 also known as CD297 and DOK1 play critical roles in cell signaling. ART4 belongs to the ADP-ribosyltransferase family and is a GPI-anchored protein with a molecular mass of about 30 kDa while DOK1 is an adapter protein with a molecular mass around 50 kDa. ART4 is expressed on erythrocytes and some lymphocyte subpopulations and DOK1 is expressed in various tissues most notably in hematopoietic cells.
Biological function summary

The two proteins engage in distinct functions within cellular mechanisms. ART4 participates in cell communication and receptor signaling on the cell surface. DOK1 acts as a modulator of signal transduction being part of signalosome complexes. Their interaction facilitates proper signaling which influences cell growth and immune responses.

Pathways

Proteins like ART4 and DOK1 play relevant roles in regulating immune cell function and hematopoiesis. ART4 is involved in the complement pathway while DOK1 connects to the Ras-MAPK signaling pathway. These proteins position themselves alongside major signaling molecules like SHC and GRB2 which participate in signal transduction cascades.

ART4 and DOK1 have implications in autoimmune diseases and leukemia. In autoimmune disorders abnormal ART4 expression alters immune responses. In leukemia DOK1's regulation of cell proliferation links it to leukemia progression correlating with proteins such as ABL1 in signaling abnormalities.
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General info

Sequence similarities

Belongs to the Arg-specific ADP-ribosyltransferase family.

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Product protocols

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Target data

See full target information Art4
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Product promise

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