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AB271510

Recombinant Mouse B2M + FCGRT protein (Biotin) (His C-Term + Avi C-Term, Avi C-Term + His C-Term)

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Recombinant Mouse B2M + FCGRT protein (Biotin) (His C-Term + Avi C-Term, Avi C-Term + His C-Term) is a Mouse Full Length protein, in the 1 to 119 aa range, expressed in HEK 293 cells, with >90%, suitable for SDS-PAGE.

View Alternative Names

Fcrn, Fcgrt, IgG receptor FcRn large subunit p51, FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor

1 Images
SDS-PAGE - Recombinant Mouse B2M + FCGRT protein (Biotin) (His C-Term + Avi C-Term, Avi C-Term + His C-Term) (AB271510)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Mouse B2M + FCGRT protein (Biotin) (His C-Term + Avi C-Term, Avi C-Term + His C-Term) (AB271510)

SDS-PAGE analysis of 5 μg ab271510.

Key facts

Purity

>90% SDS-PAGE

Expression system

HEK 293 cells

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Conjugation

Biotin

Excitation/Emission
Accession

Q61559

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.4 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.13% Sodium phosphate, 0.02% Potassium chloride

storage-buffer

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Primary Antibodies

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Proteins & Peptides

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Enzymatically biotin-labeled using Avi-tag™ technology
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Sequence info

[{"sequence":"MARSVTLVFLVLVSLTGLYAIQKTPQIQVYSRHPPENGKPNILNCYVTQFHPPHIEIQMLKNGKKIPKVEMSDMSFSKDWSFYILAHTEFTPTETDTYACRVKHASMAEPKTVYWDRDM","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":119,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"P01887","tags":[{"tag":"His","terminus":"C-Terminus"},{"tag":"Avi","terminus":"C-Terminus"}]},{"sequence":"SETRPPLMYHLTAVSNPSTGLPSFWATGWLGPQQYLTYNSLRQEADPCGAWMWENQVSWYWEKETTDLKSKEQLFLEALKTLEKILNGTYTLQGLLGCELASDNSSVPTAVFALNGEEFMKFNPRIGNWTGEWPETEIVANLWMKQPDAARKESEFLLNSCPERLLGHLERGRRNLEWKEPPSMRLKARPGNSGSSVLTCAAFSFYPPELKFRFLRNGLASGSGNCSTGPNGDGSFHAWSLLEVKRGDEHHYQCQVEHEGLAQPLTVDLDSSARSS","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":297,"aminoAcidStart":22,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q61559","tags":[{"tag":"Avi","terminus":"C-Terminus"},{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle|Store in the dark
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

B2M (Beta-2-Microglobulin) and FCGRT (Neonatal Fc Receptor) form a cellular complex. B2M is a small protein with a mass of around 11.8 kDa while FCGRT is a receptor that binds to the Fc region of IgG immunoglobulins. This complex plays an important role in the recycling and transport of IgG antibodies. B2M & FCGRT are expressed in various tissues including placenta kidney and epithelial cells. Together they help in the protection and long half-life of IgG by preventing its degradation in lysosomes.
Biological function summary

The B2M and FCGRT complex ensures proper IgG homeostasis in the body. This process allows the maintenance of high levels of circulating IgG without constant new synthesis. The B2M & FCGRT protein complex engages in transcytosis and recycling which are important for immune surveillance and pathogen neutralization. B2M associates with the major histocompatibility complex (MHC) class I molecules further aiding in antigen presentation alongside its role in the B2M protein complex.

Pathways

B2M & FCGRT interaction is part of the IgG salvage pathway. This pathway efficiently recycles IgG antibodies a step necessary for sustained immunity. The FCGRT receptor relies on the association with proteins like albumin to maintain this recycling route. B2M is also known to affect pathways including antigen processing and cross-presentation connecting it with proteins involved in adaptive immune responses.

B2M & FCGRT have implications in autoimmune diseases and nephropathies. Alterations in the function or expression of this complex can affect IgG recycling and antibody dynamics influencing autoimmune conditions like systemic lupus erythematosus. Furthermore B2M levels can serve as a marker in renal disorders particularly in glomerulonephritis. Dysregulation often aligns with proteins and receptors involved in immune regulation highlighting their role in disease progression.
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Specifications

Form

Liquid

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General info

Function

Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed : 7504013). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.

Sequence similarities

Belongs to the immunoglobulin superfamily.

Subcellular localisation

Endosome membrane

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Product protocols

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Target data

Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed : 7504013). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.
See full target information Fcgrt
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