JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB277031

Recombinant Mouse beta 2 Microglobulin + FCGRT/FCRN protein (His tag)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Mouse beta 2 Microglobulin + FCGRT/FCRN protein (His tag) is a Mouse Fragment protein, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Beta-2-microglobulin, B2m

1 Images
SDS-PAGE - Recombinant Mouse beta 2 Microglobulin + FCGRT/FCRN protein (His tag) (AB277031)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse beta 2 Microglobulin + FCGRT/FCRN protein (His tag) (AB277031)

SDS-PAGE analysis of ab277031

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P01887

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":null,"proteinLength":"Fragment","predictedMolecularWeight":"31.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q61559","tags":[{"tag":"His","terminus":"C-Terminus"}]},{"sequence":"MARSVTLVFLVLVSLTGLYAIQKTPQIQVYSRHPPENGKPNILNCYVTQFHPPHIEIQMLKNGKKIPKVEMSDMSFSKDWSFYILAHTEFTPTETDTYACRVKHDSMAEPKTVYWDRDM","proteinLength":"Fragment","predictedMolecularWeight":"11.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":119,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"P01887","tags":[]}]
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Beta-2 microglobulin (B2M) is a component of the major histocompatibility complex (MHC) class I molecules which are integral to the immune system. It is also associated with the neonatal Fc receptor (FCGRT or FcRn). The B2M protein has a mass of approximately 11.8 kDa. This protein is widely expressed with notable expression in all nucleated cells. In humans the role of B2M includes antigen presentation to T cells and it aids in the stabilization of MHC molecules.
Biological function summary

B2M interacts with the neonatal Fc receptor and is involved in the regulation of IgG antibody levels by extending their half-life. As part of the FcRn complex B2M also aids in the transport of IgG across epithelial barriers such as the intestinal lining in neonatal mammals. This complex plays a significant role in maintaining the homeostasis of IgG antibodies therefore impacting adaptive immunity.

Pathways

B2M participates in antigen processing and presentation. It forms a complex with FCGRT which is critical in the FcRn pathway responsible for the recycling and transcytosis of immunoglobulins. This interaction preserves IgG from lysosomal degradation. Additionally B2M interacts with other proteins like albumin through related pathways highlighting its involvement in protein recycling and homeostasis.

B2M is relevant to several autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. Altered B2M levels are indicative of these conditions reflecting immune dysregulation. Higher levels of B2M are also observed in multiple myeloma a disorder featuring malignancies of plasma cells. In these disease contexts B2M often serves as a biomarker alongside elevated levels of IgG or the presence of paraproteins.
style
left-column

Specifications

Form

Lyophilized

style
left-column

General info

Function

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Sequence similarities

Belongs to the beta-2-microglobulin family.

style
left-column

Product protocols

style
left-column

Target data

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
See full target information B2m

Additional targets

Fcgrt
style
left-column
style
left-column
style
right-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Assay Kits

AB181423

Human Beta-2-Microglobulin ELISA Kit

Recombinant|SimpleStep

ELISA - Human Beta-2-Microglobulin ELISA Kit (AB181423)

  • 0
  • 0
Primary Antibodies

AB75853

Anti-beta 2 Microglobulin antibody [EP2978Y]

KO Validated|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-beta 2 Microglobulin antibody [EP2978Y] (AB75853)

  • 4
  • 9
Proteins & Peptides

AB283421

Recombinant Human IGHG1 Protein

SDS-PAGE - Recombinant Human IGHG1 Protein (AB283421)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com