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AB276968

Recombinant Mouse BST2/Tetherin protein (Fc Chimera)

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Recombinant Mouse BST2/Tetherin protein (Fc Chimera) is a Mouse Fragment protein, in the 52 to 151 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

CD317, Bone marrow stromal antigen 2, BST-2, HM1.24 antigen, Bst2

1 Images
SDS-PAGE - Recombinant Mouse BST2/Tetherin protein (Fc Chimera) (AB276968)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse BST2/Tetherin protein (Fc Chimera) (AB276968)

SDS-PAGE analysis of ab276968

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

Fc tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q8R2Q8

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Complementary Products

Primary Antibodies

AB243230

Anti-BST2/Tetherin antibody [EPR20202-150]

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Immunocytochemistry/ Immunofluorescence - Anti-BST2/Tetherin antibody [EPR20202-150] (AB243230)

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Proteins & Peptides

AB114312

Recombinant Human MelanA protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human MelanA protein (GST tag N-Terminus) (AB114312)

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Primary Antibodies

AB210546

Anti-MelanA antibody [EPR20380]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MelanA antibody [EPR20380] (AB210546)

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Assay Kits

AB241912

Human BST2 Antibody Pair - BSA and Azide free

RabMAb|Recombinant

Sandwich ELISA - Human BST2 Antibody Pair - BSA and Azide free (AB241912)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"TANSVACRDGLRAQAECRNTTHLLQRQLTRTQDSLLQAETQANSCNLTVVTLQESLEKKVSQALEQQARIKELENEVTKLNQELENLRIQKETSSTVQVN","proteinLength":"Fragment","predictedMolecularWeight":"40 kDa","actualMolecularWeight":null,"aminoAcidEnd":151,"aminoAcidStart":52,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q8R2Q8","tags":[{"tag":"Fc","terminus":"N-Terminus"}]}]
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Properties and storage information

Form
Lyophilized
Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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General info

Function

IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae : human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae : ebola virus (EBOV), arenaviridae : lassa virus (LASV), and rhabdoviridae : vesicular stomatitis virus (VSV). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells.

Subcellular localisation

Late endosome

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Product protocols

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Target data

IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae : human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae : ebola virus (EBOV), arenaviridae : lassa virus (LASV), and rhabdoviridae : vesicular stomatitis virus (VSV). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells.
See full target information Bst2
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Product promise

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