Recombinant mouse BTC protein is a Mouse Full Length protein, in the 32 to 111 aa range, expressed in Escherichia coli, with >96% purity and suitable for SDS-PAGE, FuncS, HPLC.
D G N T T R T P E T N G S L C G A P G E N C T G T T P R Q K V K T H F S R C P K Q Y K H Y C I H G R C R F V V D E Q T P S C I C E K G Y F G A R C E R V D L F Y
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
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Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Bcn, Btc, Probetacellulin
Recombinant mouse BTC protein is a Mouse Full Length protein, in the 32 to 111 aa range, expressed in Escherichia coli, with >96% purity and suitable for SDS-PAGE, FuncS, HPLC.
pH: 7.4
Constituents: 100% PBS
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Protein previously labeled as Betacellulin.
The BTC protein also known as betacellulin is a member of the epidermal growth factor (EGF) family that plays an important role in cell signaling. It is a growth factor with a molecular weight of approximately 32 kDa. BTC is expressed in a range of tissues including the pancreas kidney and small intestine. This protein binds to and activates the EGF receptor (EGFR) stimulating various cellular processes. Researchers often use the BTC mouse and BTC chimeras to study its function and physiological roles due to their relevance to human biology.
BTC plays an important role in regulating cell proliferation especially in the pancreas where it influences beta-cell growth and regeneration. It operates as part of a signaling complex that interacts with other members of the EGF family impacting various cellular responses. Researchers employ experimental tools like BTC ELISA kits to quantify BTC levels in biological samples aiding in the exploration of its biological functions and mechanisms. BTC’s ability to modulate growth pathways makes it a significant molecule under investigation.
BTC participates in the EGF/EGFR signaling pathway which is essential for controlling cellular growth and differentiation. This pathway involves the interaction of BTC with other ligands such as EGF and transforming growth factor-alpha (TGF-α) altering downstream signaling events. BTC further contributes to the activation of the MAPK/ERK pathway a critical process for transmitting signals from the cell surface to the DNA in the nucleus. Through these pathways BTC impacts cellular activities and balances multiple biological functions.
BTC is linked to conditions such as diabetes and various cancers. In diabetes BTC is associated with pancreatic function particularly influencing insulin production through its role in beta-cell regulation. In cancer abnormal BTC expression or its interactions with EGFR signaling components can lead to uncontrolled cell proliferation. Researchers study BTC’s interactions with proteins like EGF and TGF-α to understand its involvement in these disorders as therapeutic targeting of this axis holds potential for treatment strategies.
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