Recombinant mouse Cathepsin D protein (Active) (His tag C-Terminus)
- Bioactive
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Recombinant mouse Cathepsin D protein (Active) (His tag C-Terminus) is a Mouse Full Length protein, in the 21 to 410 aa range, expressed in Baculovirus infected insect cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.
View Alternative Names
Cathepsin D, Ctsd
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant mouse Cathepsin D protein (Active) (His tag C-Terminus) (AB224786)
15% SDS-PAGE analysis of 3 μg ab224786.
MW : 40-57 kDa (SDS-PAGE under reducing conditions).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The enzymatic activity of Cathepsin D is important for cellular maintenance and apoptosis. This protease does not act within larger protein complexes but contributes to the degradation of extracellular and intracellular proteins. It mediates processes like antigen processing where it deconstructs proteins into peptides that are presented on major histocompatibility complex (MHC) molecules. ELISA tests can quantify its expression levels sometimes termed as CTSD activity in various biological samples offering insights into its role within cellular environments.
Pathways
Cathepsin D involvement includes the lysosomal degradation pathway and the apoptotic signaling pathway. In the lysosomal degradation pathway Cathepsin D breaks down proteins and peptides a process important for cellular recycling and energy release. It interacts with other lysosomal enzymes such as Cathepsin B in this pathway ensuring comprehensive breakdown of cellular waste. The apoptotic signaling pathway involves the regulation of programmed cell death where Cathepsin D can influence the activation of downstream proteins like Bcl-2 and Bax which control cell survival.
Specifications
Form
Liquid
Additional notes
Affinity purified
General info
Function
Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.
Sequence similarities
Belongs to the peptidase A1 family.
Post-translational modifications
N- and O-glycosylated.. Undergoes proteolytic cleavage and activation by ADAM30.
Subcellular localisation
Lysosome
Target data
Complementary Products
Product promise
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