Recombinant mouse CCL21 protein is a Mouse Full Length protein, in the 24 to 133 aa range, expressed in Escherichia coli, with >97% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS, HPLC.
S D G G G Q D C C L K Y S Q K K I P Y S I V R G Y R K Q E P S L G C P I P A I L F L P R K H S K P E L C A N P E E G W V Q N L M R R L D Q P P A P G K Q S P G C R K N R G T S K S G K K G K G S K G C K R T E Q T Q P S R G
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.
Scya21, Scya21b, Ccl21b, C-C motif chemokine 21b, 6Ckine, Beta-chemokine exodus-2, Small-inducible cytokine A21b, Thymus-derived chemotactic agent 4, TCA4
Recombinant mouse CCL21 protein is a Mouse Full Length protein, in the 24 to 133 aa range, expressed in Escherichia coli, with >97% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS, HPLC.
Determined by its ability to chemoattract total murine T cell population using a concentration range of 10.0 -100.0 ng/ml.
pH: 7.4
Constituents: 99% Phosphate Buffer, 0.87% Sodium chloride
> 97 % by HPLC analysis.
Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.
Belongs to the intercrine beta (chemokine CC) family.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
CCL21 also known as Exodus 2 or 2H26 is a chemokine with significant roles in the immune system. It is a small protein with a molecular mass of approximately 12 kDa. CCL21 is expressed in high concentrations in secondary lymphoid organs such as the spleen lymph nodes and Peyer's patches. It serves as a chemoattractant particularly for lymphocytes and dendritic cells facilitating their migration towards lymphoid organs.
CCL21 is essential for guiding immune cells to areas where they are needed for initiating immune responses. It forms a non-covalent complex with its receptor CCR7 a primary mechanism through which it exerts its biological effects. CCL21 coordinates the positioning of immune cells within the lymphoid organs ensuring a functional and effective immune response to pathogens or injuries. Its expression pattern aids in the organization of lymphoid tissue architecture and contributes to efficient trafficking of T-cells and dendritic cells.
CCL21 plays an important role in the chemokine signaling pathway and the leukocyte transendothelial migration pathway. Within these pathways CCL21 works closely with its receptor CCR7 to guide immune cell navigation and localization. This collaboration is essential for directing cells to appropriate sites in the immune system aligning CCL21 with similar proteins like CCL19 another chemokine that also interacts with CCR7.
CCL21 is associated with several immune-related conditions including rheumatoid arthritis and chronic lymphocytic leukemia. In rheumatoid arthritis CCL21 contributes to the infiltration and retention of immune cells in the synovial tissue while in chronic lymphocytic leukemia it aids in the homing of malignant cells to lymphoid organs. CCL21’s interaction with CCR7 in these diseases highlights its importance not only in immune surveillance but also in the pathology of these disorders.
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