Recombinant Mouse CD160 protein (Fc Chimera) is a Mouse Fragment protein, in the 1 to 159 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Fc tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M Q R I L M A P G Q S C C A L A I L L A I V N F Q H G G C I H V T S S A S Q K G G R L D L T C T L W H K K D E A E G L I L F W C K D N P W N C S P E T N L E Q L R V K R D P E T D G I T E K S S Q L V F T I E Q A T P S D S G T Y Q C C A R S Q K P E I Y I H G H F L S V L V T G N H T E I R Q R Q R S H P D F S H I N G T L
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
CD160 antigen. Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (By similarity). Receptor for both classical and non-classical MHC class I molecules (PubMed:16177084). Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (PubMed:25711213). On activated CD4+ T cells, interacts with TNFRSF14 and down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (By similarity). In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (PubMed:22801499). CD160 antigen, soluble form. The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions.
Alternative names
CD160, By55, Cd160, CD160 antigen, Natural killer cell receptor BY55
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Recombinant Mouse CD160 protein (Fc Chimera) is a Mouse Fragment protein, in the 1 to 159 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Fc tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- O88875-1
- Animal free
- No
- Species
- Mouse
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M Q R I L M A P G Q S C C A L A I L L A I V N F Q H G G C I H V T S S A S Q K G G R L D L T C T L W H K K D E A E G L I L F W C K D N P W N C S P E T N L E Q L R V K R D P E T D G I T E K S S Q L V F T I E Q A T P S D S G T Y Q C C A R S Q K P E I Y I H G H F L S V L V T G N H T E I R Q R Q R S H P D F S H I N G T L
- Accession
- O88875
- Protein length
- Fragment
- Predicted molecular weight
- 41.9 kDa
- Amino acids
- 1 to 159
- Nature
- Recombinant
- Tags
- Fc tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
CD160 antigen
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CD160 also known as BY55 is a glycosylphosphatidylinositol (GPI)-anchored protein with a molecular weight of approximately 27 kDa. This protein is expressed on the surface of natural killer (NK) cells CD8+ T cells and certain NKT cells. It functions as a receptor for MHC class I molecules and HLA-C playing a role in regulating immune responses. Researchers have also identified its expression in some endothelial cells.
- Biological function summary
The protein CD160 plays a role in immune modulation by interacting with major histocompatibility complex (MHC) class I ligands. It participates in the immune response by enhancing cytotoxic activity in NK and CD8+ T cells therefore influencing cell-mediated immunity. CD160 does not associate with large signal transduction complexes but operates as a standalone receptor capable of mediating cellular effects upon ligand binding. Although primarily known for its role in immune modulation CD160 can impact endothelial functions suggesting a broader biological significance.
- Pathways
CD160 engages in the pathway associated with immune cell signaling. It operates within the natural killer cell signaling cascade contributing to the regulation of cell-mediated cytotoxicity. In the context of adaptive immunity CD160 influences the T cell receptor signaling pathway indirectly coordinating its actions with proteins such as NKG2D and PD-1. These interactions are important in how immune cells assess threats and modulate responses.
- Associated diseases and disorders
CD160 has implications in chronic inflammatory and autoimmune conditions. It is linked to disorders such as inflammatory bowel disease and psoriasis where immune regulation is disrupted. Its interaction with other proteins such as PD-1 may either exacerbate or alleviate symptoms depending on the pathological context. Understanding CD160's role provides insights into therapeutic strategies aimed at modulating immune responses in these conditions.
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1 product image
SDS-PAGE - Recombinant Mouse CD160 protein (Fc Chimera) (ab276930)
SDS-PAGE analysis of ab276930
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