Recombinant Mouse CD93 protein (His tag C-Terminus)
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Recombinant Mouse CD93 protein (His tag C-Terminus) is a Mouse Fragment protein, in the 23 to 572 aa range, expressed in Insect cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
CD93, Aa4, C1qr1, C1qrp, Ly68, Cd93, Complement component C1q receptor, C1q/MBL/SPA receptor, Cell surface antigen AA4, Complement component 1 q subcomponent receptor 1, Lymphocyte antigen 68, C1qR(p), C1qRp, Ly-68
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Mouse CD93 protein (His tag C-Terminus) (AB208464)
15% SDS-PAGE analysis of ab208464 (3 μg)
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CD93 contributes to cellular processes through its role in the clearance of apoptotic cells and immune surveillance. It also partakes in angiogenesis facilitating the growth of new blood vessels. CD93 often functions as part of a larger complex in binding with other molecules to support cellular communication. By modulating the immune response CD93 ensures efficient removal of cellular debris maintaining homeostasis and preventing autoimmune reactions.
Pathways
CD93 operates within the innate immune response and complement system pathways. It closely interacts with other proteins such as C1q which is part of the complement activation pathway. This interaction supports the clearance of immune complexes and cellular debris. By facilitating these processes CD93 aids in maintaining the balance between immune activation and tolerance.
Specifications
Form
Liquid
Additional notes
Affinity purified
General info
Function
Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion (PubMed : 15004139, PubMed : 20439917, PubMed : 38441970). Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2) (PubMed : 15004139). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration. Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands. Both ligands play a non-redundant role in CD93-mediated endothelial cell function (By similarity). Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function (PubMed : 38441970).
Post-translational modifications
N- and O-glycosylated.. Phosphorylated on Tyr-620 and Tyr-636 by SRC; these phosphorylations promote endothelial cell adhesion and migration.
Target data
Complementary Products
![Flow Cytometry (Intracellular) - Anti-CD93 antibody [EPR5386] (AB134079)](https://content.abcam.com/products/images/cd93-antibody-epr5386-ab134079--flow-cytometry-intracellular-img38626.jpg)
Product promise
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