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AB235732

Recombinant Mouse CELA2A protein (His tag)

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Recombinant Mouse CELA2A protein (His tag) is a Mouse Full Length protein, in the 31 to 271 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

Ela-2, Ela2, Ela2a, Chymotrypsin-like elastase family member 2A, Elastase-2, Elastase-2A

1 Images
SDS-PAGE - Recombinant Mouse CELA2A protein (His tag) (AB235732)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse CELA2A protein (His tag) (AB235732)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel using ab235732.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P05208

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"VVGGQEATPNTWPWQVSLQVLSSGRWRHNCGGSLVANNWVLTAAHCLSNYQTYRVLLGAHSLSNPGAGSAAVQVSKLVVHQRWNSQNVGNGYDIALIKLASPVTLSKNIQTACLPPAGTILPRNYVCYVTGWGLLQTNGNSPDTLRQGRLLVVDYATCSSASWWGSSVKSSMVCAGGDGVTSSCNGDSGGPLNCRASNGQWQVHGIVSFGSSLGCNYPRKPSVFTRVSNYIDWINSVMARN","proteinLength":"Full Length","predictedMolecularWeight":"29.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":271,"aminoAcidStart":31,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P05208","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CELA2A also known as chymotrypsin-like elastase family member 2A is a serine protease enzyme with an approximate mass of 28 kDa. It functions primarily by breaking down protein components specifically elastin which is its substrate. This enzyme is highly expressed in the pancreas where it plays a role in the digestive processes by contributing to the degradation of dietary proteins.
Biological function summary

The role of this enzyme extends beyond simple protein digestion. It participates in complex interactions within the digestive tract facilitating the proper breakdown of ingested nutrients. CELA2A forms part of a protease family complex that includes other important enzymes that collaborate in the digestive system. Chymotrypsin-like elastase complements the actions of related enzymes ensuring the digestive tract functions efficiently.

Pathways

CELA2A significantly engages in digestive proteolytic pathways. It works alongside enzymes such as trypsin and chymotrypsin within the protein digestion and absorption pathway. This involvement is important because it promotes effective protein breakdown which aids nutrient assimilation for the organism's metabolic needs. CELA2A interacts closely with these enzymes maintaining a balance in proteolytic activity necessary for optimal digestive health.

CELA2A relates to conditions such as pancreatitis and cystic fibrosis. In pancreatitis deregulation of proteolytic activity leads to pancreatic tissue damage with CELA2A being one of the implicated proteases. In cystic fibrosis mutations affecting related transport proteins can alter the expression and effectiveness of CELA2A and other digestive proteases compromising nutrient absorption and digestive health. Proper regulation of CELA2A and its related proteins is essential to minimize the impact of these conditions.
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Specifications

Form

Liquid

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General info

Function

Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity.

Sequence similarities

Belongs to the peptidase S1 family. Elastase subfamily.

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Product protocols

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Target data

Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity.
See full target information Cela2a
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