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AB276992

Recombinant Mouse CRELD1 protein (His tag)

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Recombinant Mouse CRELD1 protein (His tag) is a Mouse Fragment protein, in the 1 to 362 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Protein disulfide isomerase Creld1, Cysteine-rich with EGF-like domain protein 1, Creld1

1 Images
SDS-PAGE - Recombinant Mouse CRELD1 protein (His tag) (AB276992)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse CRELD1 protein (His tag) (AB276992)

SDS-PAGE analysis of ab276992

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q91XD7

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAPLPPRGLVPSLLWCLSLFLSLPGPVWLQPSPPPHPSPRAEPHPCHTCRALVDNFNKGLERTIRDNFGGGNTAWEEEKLSKYKDSETRLVEVLEGVCSRSDFECHRLLELSEELVENWWFHRQQEAPDLFQWLCSDSLKLCCPSGTFGPSCLPCPGGTERPCGGYGQCEGEGTRGGSGHCDCQAGYGGEACGQCGLGYFEAERNSSHLVCSACFGPCARCTGPEESHCLQCKKGWALHHLKCVDIDECGTEQATCGADQFCVNTEGSYECRDCAKACLGCMGAGPGRCKKCSRGYQQVGSKCLDVDECETVVCPGENEKCENTEGGYRCVCAEGYRQEDGICVKEQVPESAGFFAEMTEDE","proteinLength":"Fragment","predictedMolecularWeight":"37.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":362,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q91XD7","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CRELD1 also known as cysteine-rich with EGF-like domains 1 is a protein implicated in cell-cell interactions or signaling mechanisms. This protein has an approximate molecular mass of 57.5 kDa. It is known for its expression in the heart specifically in the outflow tract during embryonic development and also in other tissues such as the kidney and lung. CRELD1 plays a role in various cellular processes important for normal organ development and function.
Biological function summary

CRELD1 is involved in the structural assembly of the extracellular matrix. It is part of a complex that contributes to cellular adhesion and possibly enhances communication between cells. This protein's activity appears important for cardiac tissue development particularly in the forming of the cardiac septum and valvular structures. CRELD1 facilitates interactions that support proper organogenesis.

Pathways

CRELD1 associates with both the Notch signaling pathway and the Wnt signaling pathway indicative of its role in developmental signaling events. Within the Notch pathway CRELD1 interacts with other proteins like Jagged and Delta facilitating critical embryonic development signals. Meanwhile in the Wnt pathway CRELD1's involvement further highlights its role in regulating cellular proliferation and differentiation processes which are essential during development.

CRELD1 has shown associations with congenital heart defects particularly atrioventricular septal defects (AVSD). Mutations in the CRELD1 gene have been linked to altered heart structure and function. Additionally research indicates that CRELD1 possibly interacts with proteins like TGFB3 in the context of heart development disorders where disruptions in signaling can cause developmental defects. Understanding these interactions assists in elucidating pathways that lead to such congenital anomalies.
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Specifications

Form

Lyophilized

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General info

Function

Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (PubMed : 30407909).

Sequence similarities

Belongs to the CRELD family.

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Product protocols

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Target data

Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (PubMed : 30407909).
See full target information Creld1
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