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AB276991

Recombinant Mouse CRELD2 protein (His tag)

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Recombinant Mouse CRELD2 protein (His tag) is a Mouse Full Length protein, in the 1 to 350 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.

View Alternative Names

Protein disulfide isomerase Creld2, Cysteine-rich with EGF-like domain protein 2, Creld2

1 Images
SDS-PAGE - Recombinant Mouse CRELD2 protein (His tag) (AB276991)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse CRELD2 protein (His tag) (AB276991)

SDS-PAGE analysis of ab276991

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE, FuncS

applications

Biologically active

Yes

Biological activity

Measured by the ability of the immobilized protein to support the adhesion of ATDC5 mouse chondrogenic cells. When 5 x 10^4 cells/well are added to mCRELD2-coated plates (0.625 μg/mL, 100 μL/well),approximately 20% cells will adhere after 60 minutes at 37°C.

Accession

Q9CYA0

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Complementary Products

Assay Kits

AB313540

Human CRELD2 ELISA Kit

Sandwich ELISA - Human CRELD2 ELISA Kit (AB313540)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"" } } }
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Sequence info

[{"sequence":"MHLLLAAAFGLLLLLPPPGAVASRKPTMCQRCRTLVDKFNQGMANTARKNFGGGNTAWEEKTLSKYEFSEIRLLEIMEGLCDSSDFECNQLLEQQEEQLEAWWQTLKKEHPNLFEWFCVHTLKACCLPGTYGPDCQECQGGSERPCSGNGYCSGDGSRQGDGSCQCHTGYKGPLCIDCTDGFFSLQRNETHSICSACDESCKTCSGPSNKDCIQCEVGWARVEDACVDVDECAAETSPCSDGQYCENVNGSYTCEDCDSTCVGCTGKGPANCKECIAGYTKESGQCTDIDECSLEEKACKRKNENCYNVPGSFVCVCPEGFEETEDACVQTAEGKVTEENPTQPPSREDL","proteinLength":"Full Length","predictedMolecularWeight":"37.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":350,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9CYA0","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
True
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cysteine-Rich with EGF-Like Domains 2 (CRELD2) is a protein encoded by the CRELD2 gene also known as Cysteine-Rich with EGF-Like Domains Protein 2. The protein consists of 362 amino acids and has a molecular mass of approximately 39 kDa. CRELD2 expresses mainly in the endoplasmic reticulum and can also be found in many tissues with notable levels in neural tissues and cardiac muscle. This protein functions as a chaperone influencing the folding and stability of other proteins within the cell.
Biological function summary

CRELD2 plays a significant role in the endoplasmic reticulum stress response a process important for maintaining cellular homeostasis. The protein modulates cellular stress pathways and associates with several other chaperone proteins assisting in the proper folding of newly synthesized proteins. It does not associate with a particular protein complex but functions independently to ensure efficient protein synthesis and folding under stress conditions.

Pathways

CRELD2 integrates primarily with the unfolded protein response (UPR) pathway activated during ER stress to restore normal function by halting protein translation and facilitating protein folding. In this pathway CRELD2 interacts with key proteins such as ATF6 and IRE1. These interactions enhance its role in correcting misfolded proteins and prevent the accumulation of toxic protein aggregates within cells.

CRELD2 links to several conditions especially those related to disrupted protein homeostasis like Alzheimer's disease and cardiac abnormalities. Disruptions in CRELD2 expression can impact protein folding and stress responses which contributes to the pathogenesis of these diseases. It also connects with proteins such as amyloid precursor protein (APP) and cardiac myosin emphasizing its role in neuronal and cardiac health.
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Specifications

Form

Lyophilized

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General info

Function

Protein disulfide isomerase (Probable). Might play a role in the unfolded protein response (Probable). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (By similarity).

Sequence similarities

Belongs to the CRELD family.

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Product protocols

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Target data

Protein disulfide isomerase (Probable). Might play a role in the unfolded protein response (Probable). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (By similarity).
See full target information Protein disulfide isomerase Creld2
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Product promise

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