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AB276995

Recombinant Mouse CRISP1 protein (His tag)

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Recombinant Mouse CRISP1 protein (His tag) is a Mouse Full Length protein, in the 1 to 244 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Aeg-1, Aeg1, Crisp1, Cysteine-rich secretory protein 1, CRISP-1, Acidic epididymal glycoprotein 1, Sperm-coating glycoprotein 1, SCP 1

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SDS-PAGE - Recombinant Mouse CRISP1 protein (His tag) (AB276995)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse CRISP1 protein (His tag) (AB276995)

SDS-PAGE analysis of ab276995

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q03401

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MALMLVLFFLAAVLPPSLLQDSSQENRLEKLSTTKMSVQEEIVSKHNQLRRMVSPSGSDLLKMEWNYDAQVNAQQWADKCTFSHSPIELRTTNLRCGENLFMSSYLASWSSAIQGWYNEYKDLTYDVGPKQPDSVVGHYTQVVWNSTFQVACGVAECPKNPLRYYYVCHYCPVGNYQGRLYTPYTAGEPCASCPDHCEDGLCTNSCGHEDKYTNCKYLKKMLSCEHELLKKGCKATCLCEGKIH","proteinLength":"Full Length","predictedMolecularWeight":"27.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":244,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q03401","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CRISP1 also known as Cysteine-Rich Secretory Protein 1 acts mechanically by modulating sperm-egg interactions during fertilization. It has a molecular mass of approximately 25 kDa. Researchers observe its expression mainly in the epididymis where it participates in the regulation of sperm maturation and capacitation. The gene encoding CRISP1 resides on chromosome 6 in humans where it expresses predominantly in reproductive tissues.
Biological function summary

CRISP1 influences sperm adhesion to the egg's zona pellucida essential for the sperm to penetrate the oocyte. This target does not form part of a complex but works in conjunction with other proteins in the fertilization process. Evidence suggests CRISP1 binds to specific sites on the sperm surface facilitating their ability to bind to the egg and support successful fertilization.

Pathways

CRISP1 plays an integral role in reproductive pathways influencing sperm-egg recognition and binding. It operates closely with proteins such as CRISP2 which also contribute to sperm maturation and fertilization processes. In these pathways CRISP1 remains an important factor that ensures optimal sperm function and interaction with the egg critical steps for achieving fertilization.

Scientists have associated CRISP1 with fertility-related conditions. Low levels or dysfunction in CRISP1 can contribute to unexplained male infertility where sperm quality or function is poor despite normal sperm count. The protein interacts with other fertility-associated proteins like CatSper highlighting its role in this disorder. Studies continue to explore CRISP1's potential implications in reproductive health and its significance as a biomarker or therapeutic target in infertility treatments.
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Specifications

Form

Lyophilized

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General info

Function

This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens.

Sequence similarities

Belongs to the CRISP family.

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Product protocols

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Target data

This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens.
See full target information Crisp1
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