Recombinant mouse CXCL14 protein (Active) is a Mouse Full Length protein, in the 23 to 99 aa range, expressed in Escherichia coli, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS, HPLC.
S K C K C S R K G P K I R Y S D V K K L E M K P K Y P H C E E K M V I V T T K S M S R Y R G Q E H C L H P K L Q S T K R F I K W Y N A W N E K R R V Y E E
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
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Chemotactic for CESS B-cells and THP-1 monocytes, but not T-cells.
Bmac, Kec, Ks1, Mip2g, Scyb14, Cxcl14, C-X-C motif chemokine 14, B-cell and monocyte-activating chemokine, Chemokine BRAK, Kidney-expressed chemokine CXC, MIP-2G, Small-inducible cytokine B14
Recombinant mouse CXCL14 protein (Active) is a Mouse Full Length protein, in the 23 to 99 aa range, expressed in Escherichia coli, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS, HPLC.
pH: 7.4
Constituents: 94% Phosphate Buffer, 5% Trehalose, 0.87% Sodium chloride
and HPLC analyses.
Chemotactic for CESS B-cells and THP-1 monocytes, but not T-cells.
Belongs to the intercrine alpha (chemokine CxC) family.
Ubiquitinated, followed by degradation by the proteasome.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
The CXCL14 protein also known as BRAK is a small cytokine belonging to the CXC chemokine family. It has a molecular mass of 8.9 kDa and is expressed in various tissues with high levels in the kidney lung skin and reproductive tissues. It does not normally circulate in the blood but rather acts in tissues. The protein plays a role in immune system regulation by being involved in the migration of immune cells.
CXCL14 influences cell signaling pathways that regulate immune responses and tissue homeostasis. It engages in the attraction of immune cells like monocytes and dendritic cells to specific tissues. While CXCL14 is not part of a larger complex its function in modulating local immune environments is significant. This protein’s role in immune surveillance contributes to both normal physiological conditions and response to pathology.
Interactions of CXCL14 involve key signaling cascades. The protein is part of pathways that regulate inflammation and cell movement including the MAPK and PI3K signaling pathways. Related proteins such as CXCR4 and CCR2 interact within these pathways to coordinate cell signaling and chemotaxis. These interactions facilitate communication between cells and regulate responses essential for maintaining tissue integrity.
CXCL14 links with conditions like cancer and obesity. Studies suggest that CXCL14 may play a dual role in cancer acting as a tumor suppressor in certain contexts by influencing immune cell infiltration into tumors. In obesity altered expression patterns of CXCL14 have been observed highlighting potential roles in adipose tissue regulation. Proteins like CXCR4 are also connected with CXCL14 in these disease contexts suggesting complex interdependencies within the cellular communication network.
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