Recombinant Mouse CXCL16 protein is a Mouse Fragment protein, in the 27 to 201 aa range, expressed in Mammalian, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
>95% SDS-PAGE
< 1 EU/µg
Mammalian
His tag C-Terminus
SDS-PAGE, HPLC
No
N Q G S V A G S C S C D R T I S S G T Q I P Q G T L D H I R K Y L K A F H R C P F F I R F Q L Q S K S V C G G S Q D Q W V R E L V D C F E R K E C G T G H G K S F H H Q K H L P Q A S T Q T P E A A E G T P S D T S T P A H S Q S T Q H S T L P S G A L S L N K E H T Q P W E M T T L P S G Y G L E A R P E A E A N E K Q Q D D R Q Q E A P G A G A S T P A W V D H H H H H H
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Select an associated product type
Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis.
C-X-C motif chemokine 16, Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein, Small-inducible cytokine B16, Transmembrane chemokine CXCL16, SR-PSOX, Cxcl16, Srpsox
Recombinant Mouse CXCL16 protein is a Mouse Fragment protein, in the 27 to 201 aa range, expressed in Mammalian, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
>95% SDS-PAGE
< 1 EU/µg
Mammalian
His tag C-Terminus
SDS-PAGE, HPLC
No
No
Mouse
Reconstitute in 3X PBS
pH: 7.4
Constituents: 100% PBS
N Q G S V A G S C S C D R T I S S G T Q I P Q G T L D H I R K Y L K A F H R C P F F I R F Q L Q S K S V C G G S Q D Q W V R E L V D C F E R K E C G T G H G K S F H H Q K H L P Q A S T Q T P E A A E G T P S D T S T P A H S Q S T Q H S T L P S G A L S L N K E H T Q P W E M T T L P S G Y G L E A R P E A E A N E K Q Q D D R Q Q E A P G A G A S T P A W V D H H H H H H
Fragment
20.13 kDa
27 to 201
Recombinant
His tag C-Terminus
Lyophilized
Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis.
Belongs to the intercrine alpha (chemokine CxC) family.
Glycosylated.
Blue Ice
A few weeks
-20°C
-20°C
Avoid freeze / thaw cycle, Reconstitute for long term storage
This supplementary information is collated from multiple sources and compiled automatically.
CXCL16 also known as SR-PSOX is a chemokine that functions primarily in cellular signaling. It weighs approximately 32 kDa and exists in both membrane-bound and soluble forms. Primarily found in the spleen liver lungs and kidneys CXCL16 gets highly expressed on the surface of antigen-presenting cells such as dendritic cells and macrophages. This expression enables CXCL16 to perform its role in cell migration and adhesion by binding to its receptor CXCR6.
CXCL16 plays a critical role in the immune response by mediating leukocyte migration. It acts as a chemoattractant for T cells especially those expressing the CXCR6 receptor facilitating their movement to sites of inflammation or injury. CXCL16 is not known to be part of a larger protein complex but interacts independently to moderate immune functions. It also participates in scavenging oxidized low-density lipoproteins linking it to processes in atherogenesis.
CXCL16 is an important player in the inflammatory and immune pathways. It is involved in the NF-kB signaling pathway which regulates inflammatory responses and the chemokine signaling pathway. Through these pathways CXCL16 closely interacts with other chemokines and cytokines such as CCR5 and IL-8 helping coordinate immune surveillance and inflammatory cascade.
CXCL16 is heavily implicated in atherosclerosis and rheumatoid arthritis. In atherosclerosis CXCL16 contributes to the accumulation of macrophages and foam cell formation in plaques. This connection associates it with inflammatory molecules like TNF-alpha. In rheumatoid arthritis CXCL16 expression is increased in synovial tissues contributing to tissue damage and inflammation potentially linked through interactions with other inflammatory mediators such as IL-6.
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