Recombinant mouse CXCL9 protein is a Mouse Full Length protein, in the 22 to 126 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, FuncS.
T L V I R N A R C S C I S T S R G T I H Y K S L K D L K Q F A P S P N C N K T E I I A T L K N G D Q T C L D P D S A N V K K L M K E W E K K I N Q K K K Q K R G K K H Q K N M K N R K P K T P Q S R R R S R K T T
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info 0.0001-0.001 µg/mL | Notes Chemoattraction of human T lymphocytes. |
May be a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response.
Mig, Scyb9, Cxcl9, C-X-C motif chemokine 9, Gamma-interferon-induced monokine, Monokine induced by interferon-gamma, Protein m119, Small-inducible cytokine B9, MIG, MuMIG
Recombinant mouse CXCL9 protein is a Mouse Full Length protein, in the 22 to 126 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, FuncS.
ab50083 purity was assessed also by HPLC.Endotoxin level is less than 0.1 ng per µg (1EU/µg).
May be a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response.
Belongs to the intercrine alpha (chemokine CxC) family.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
CXCL9 also known as MIG (monokine induced by gamma interferon) is a small cytokine protein with a molecular weight of approximately 13 kDa. CXCL9 exhibits strong chemotactic properties and is secreted by various cells including endothelial cells macrophages and fibroblasts upon stimulation by interferon-gamma. Its expression primarily occurs in inflamed tissues and is associated with immune responses. Researchers often use tools like a CXCL9 ELISA kit or CXCL9 test to measure its expression levels in biological samples aiding in understanding its role in various conditions.
This cytokine plays a pivotal role in the immune system by regulating leukocyte trafficking. CXCL9 exerts its function through binding to the CXCR3 receptor attracting T cells towards sites of inflammation or infection. This interaction is significant in mediating immune surveillance and host defense. CXCL9 does not form part of a larger protein complex but its chemokine activity is critical for immune system coordination. Scientific studies often highlight its involvement through CXCL9 function and expression analysis.
CXCL9 significantly influences the chemokine signaling pathway and the Th1-type adaptive immune response. Within these pathways it interacts closely with other chemokines like CXCL10 and CXCL11 which also bind to the CXCR3 receptor. These pathways highlight the coordinated mobilization of T cells during immune challenges and inflammation emphasizing how CXCL9 is often examined alongside these related chemokines in research settings.
CXCL9 is notably associated with autoimmune diseases such as rheumatoid arthritis and inflammatory conditions like psoriasis. Its elevated expression is often observed in affected tissues contributing to disease pathogenesis through T cell migration and activation. In these contexts CXCL9 is frequently examined alongside other pro-inflammatory cytokines such as interferon-gamma and TNF-alpha which are known to modulate its expression and activity impacting disease progression and therapeutic strategies.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com