Recombinant Mouse Entactin/NID protein is a Mouse Fragment protein, in the 428 to 665 aa range, expressed in Yeast, with >90% purity and suitable for SDS-PAGE.
>90% SDS-PAGE
Yeast
Tag free
SDS-PAGE
No
S P Q R V N G K V K G R I F V G S S Q V P V V F E N T D L H S Y V V M N H G R S Y T A I S T I P E T V G Y S L L P L A P I G G I I G W M F A V E Q D G F K N G F S I T G G E F T R Q A E V T F L G H P G K L V L K Q Q F S G I D E H G H L T I S T E L E G R V P Q I P Y G A S V H I E P Y T E L Y H Y S S S V I T S S S T R E Y T V M E P D Q D G A A P S H T H I Y Q W R Q T I T F Q E C A H D D A R P A L P S T Q Q L S V D S V F V L Y N K E E R I L R Y A L S N S I G P V R D G S P D A
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Select an associated product type
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.
Nidogen-1, NID-1, Entactin, Nid1, Ent
Recombinant Mouse Entactin/NID protein is a Mouse Fragment protein, in the 428 to 665 aa range, expressed in Yeast, with >90% purity and suitable for SDS-PAGE.
>90% SDS-PAGE
Yeast
Tag free
SDS-PAGE
No
No
Mouse
pH: 7.2 - 7.4
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
S P Q R V N G K V K G R I F V G S S Q V P V V F E N T D L H S Y V V M N H G R S Y T A I S T I P E T V G Y S L L P L A P I G G I I G W M F A V E Q D G F K N G F S I T G G E F T R Q A E V T F L G H P G K L V L K Q Q F S G I D E H G H L T I S T E L E G R V P Q I P Y G A S V H I E P Y T E L Y H Y S S S V I T S S S T R E Y T V M E P D Q D G A A P S H T H I Y Q W R Q T I T F Q E C A H D D A R P A L P S T Q Q L S V D S V F V L Y N K E E R I L R Y A L S N S I G P V R D G S P D A
Fragment
26.3 kDa
428 to 665
Recombinant
Liquid
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.
N- and O-glycosylated.
Blue Ice
-20°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Previously labelled as Entactin.
This supplementary information is collated from multiple sources and compiled automatically.
Entactin also known as nidogen-1 or NID1 is a significant glycoprotein of the extracellular matrix with a molecular mass of approximately 150 kDa. This protein is often referred to as nidogen and nidogen 1. It localizes mainly in basement membranes across various tissues. Entactin serves as an important structural component and mediator between other extracellular molecules contributing significantly to the maintenance and integrity of the basement membrane structure.
Entactin interacts closely with laminin and type IV collagen within the extracellular matrix forming an important part of the basement membrane complex. This protein aids in the stabilization and linkage of these matrices playing an essential role in cellular adhesion and migration processes. By facilitating the structural assembly of basement membranes entactin supports cellular signaling pathways that are involved in tissue development and repair.
Entactin acts within the integrin signaling pathway and the basement membrane formation pathway. It interacts with integrin receptors on the cell surface thereby influencing processes like cell adhesion and morphogenesis. Through these pathways entactin signals in coordination with laminins and collagens building a robust structural framework necessary for tissue integrity and function.
Entactin's disruption has links to cancer and certain genetic disorders affecting basement membrane integrity. Aberrant expression or dysfunction of entactin can contribute to the progression of tumor invasion due to its pivotal role in cellular adhesion. Furthermore it associates with muscular dystrophies through interactions with laminins and collagens highlighting its importance in maintaining normal tissue architecture and function.
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