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AB276886

Recombinant mouse Eph receptor A6 protein (His tag)

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Recombinant mouse Eph receptor A6 protein (His tag) is a Mouse Fragment protein, in the 1 to 546 aa range, expressed in HEK 293 cells, with >97%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.

View Alternative Names

Ehk-2, Ehk2, Epha6, Ephrin type-A receptor 6, EPH homology kinase 2, EHK-2

2 Images
Functional Studies - Recombinant mouse Eph receptor A6 protein (His tag) (AB276886)
  • FuncS

Supplier Data

Functional Studies - Recombinant mouse Eph receptor A6 protein (His tag) (AB276886)

Measured by its binding ability in a functional ELISA.

Immobilized recombinant mouse EphA6 at 2 μg/ml (100 μl/well) can bind recombinant human EphrinA3 at a linear range of 0.31-10 ng/ml.

SDS-PAGE - Recombinant mouse Eph receptor A6 protein (His tag) (AB276886)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant mouse Eph receptor A6 protein (His tag) (AB276886)

SDS-PAGE analysis of ab276886

Key facts

Purity

>97% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE, FuncS

applications

Biologically active

Yes

Biological activity

Measured by its binding ability in a functional ELISA.

Immobilized recombinant mouse EphA6 at 2 μg/ml (100 μl/well) can bind recombinant human EphrinA3 at a linear range of 0.31-10 ng/ml.

Accession

Q62413

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGGCEVREFLLQFGFFLPLLTAWTGDCSHVSNQVVLLDTTTVMGELGWKTYPLNGWDAITEMDEHNRPIHTYQVCNVMEPNQNNWLRTNWISRDAAQKIYVEMKFTLRDCNSIPWVLGTCKETFNLYYIESDESHGTKFKPSQYIKIDTIAADESFTQMDLGDRILKLNTEIREVGPIERKGFYLAFQDIGACIALVSVRVFYKKCPFTVRNLAMFPDTIPRVDSSSLVEVRGSCVKSAEERDTPKLYCGADGDWLVPLGRCICSTGYEEIEGSCHACRPGFYKAFAGNTKCSKCPPHSSTYVEATSVCHCEKGYFRAEKDPPSMACTRPPSAPRNVAFNINETALILEWSPPSDTGGRKDLTYSVICKKCGLDTTQCEDCGGGLRFIPRHTGLINNSVVVLDFVSHVNYTFEIEAMNGVSELSISPKPFTAITVTTDHDAPSLIGMMRKDWASQNSLALSWQAPAFSNGAILDYEIKYYEKEHEQLTYSSTRSKAPSVIVTGLKPATTYIFHIRVRTATGYSGYSQKFEFETGDETSDMAAEQGQ","proteinLength":"Fragment","predictedMolecularWeight":"59.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":546,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q62413","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
True
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Eph receptor A6 also known as EphA6 acts as a receptor tyrosine kinase which belongs to the ephrin receptor subfamily. Its structure involves a mass of approximately 110 kDa. EphA6 is expressed in various tissues with notably high expression in the brain. It plays a mechanical role by binding ephrin ligands which leads to receptor activation and downstream signaling.
Biological function summary

Ephrin-Eph receptor interactions regulate processes like cell adhesion migration and development with EphA6 influencing neural development and plasticity. It does not form a complex on its own but interacts with ephrin ligands to initiate cellular responses. These functions are important for maintaining cellular architecture and communication during development.

Pathways

EphA6 participates in the Ephrin signaling pathway engaging in complex interactions to mediate developmental processes. This receptor also involves itself in the neural development pathway. Proteins like EphA2 and ephrin-A1 frequently interact with EphA6 within these pathways facilitating various signaling cascades that are significant for cellular architecture.

Abnormal expression or function of EphA6 has been associated with neurodegenerative disorders like Alzheimer's disease. Changes in EphA6 participate in disruption of synaptic connections. Within cancer biology EphA6 has been implicated in tumor progression and metastasis. In these contexts it may interact with other proteins such as EGFR influencing cellular behaviors related to malignancy.
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Specifications

Form

Lyophilized

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General info

Function

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.

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Product protocols

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Target data

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
See full target information Epha6
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