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AB191954

Recombinant Mouse Ephrin A4 protein

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Recombinant Mouse Ephrin A4 protein is a Mouse Full Length protein, in the 27 to 176 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

Epl4, Eplg4, Lerk4, Efna4, Ephrin-A4, EPH-related receptor tyrosine kinase ligand 4, LERK-4

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

Fc tag C-Terminus

Applications

SDS-PAGE, HPLC

applications

Biologically active

No

Accession

O08542

Animal free

No

Carrier free

No

Species

Mouse

Reconstitution

Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"RHPIYWNSSNPRLLRGDAVVELGFNDYLDIFCPHYESPGPPEGPETFALYMVDWSGYEACTAEGANAFQRWNCSMPFAPFSPVRFSEKIQRYTPFPLGFEFLPGETYYYISVPTPESPGRCLRLQVSVCCKESGSSHESAHPVGSPGESGVDDIEGRMDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK","proteinLength":"Full Length","predictedMolecularWeight":"43.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":176,"aminoAcidStart":27,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"O08542","tags":[{"tag":"Fc","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle|Reconstitute for long term storage
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Ephrin A4 also known as EFNA4 is part of the ephrin family of proteins. It interacts with Eph receptors and primarily functions as a ligand—a molecule that binds to another to form a complex—within this signaling system. Ephrin A4 is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) linkage and its molecular mass is approximately 21 kDa. The expression of Ephrin A4 can be found in various tissues including the brain lungs and kidneys indicating its diverse roles in bodily functions.
Biological function summary

Ephrin A4 plays significant roles in the development and function of the nervous system. It works within the ephrin/Eph receptor signaling system impacting processes such as cell positioning and tissue boundary formation. Ephrin A4 is not an isolated component; it acts as part of a complex with Eph receptors influencing cell adhesion and shape. These interactions guide the cellular processes required for proper embryonic development.

Pathways

Ephrin A4 is involved in the ephrin signaling pathway and the MAPK/ERK pathway. These pathways regulate cell proliferation differentiation and migration which are essential for developmental processes. Ephrin A4 interacts with EphA receptors influencing these signaling cascades. This connection shows its significant influence on various cellular processes including those relevant in neural patterning.

Ephrin A4 has associations with certain cancers and neurodegenerative illnesses. In cancer particularly breast cancer Ephrin A4 dysregulation links to uncontrolled cell proliferation and migration often in connection with EphA2 receptor overexpression. Furthermore in neurodegenerative conditions like Alzheimer's disease altered ephrin signaling involves the degradation of neural structures implicating interactions with EphB2. These associations underline the importance of Ephrin A4 in maintaining cellular and tissue health.
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Specifications

Form

Lyophilized

Additional notes

determined by SEC-HPLC and reducing SDS-PAGE.

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General info

Function

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils (By similarity).

Sequence similarities

Belongs to the ephrin family.

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Product protocols

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Target data

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils (By similarity).
See full target information Efna4
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