Recombinant mouse Ephrin B2 protein (His tag)
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Recombinant mouse Ephrin B2 protein (His tag) is a Mouse Fragment protein, in the 1 to 232 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.
View Alternative Names
Elf2, Epl5, Eplg5, Htkl, Lerk5, Efnb2, Ephrin-B2, ELF-2, EPH-related receptor tyrosine kinase ligand 5, HTK ligand, LERK-5, HTK-L
- FuncS
Supplier Data
Functional Studies - Recombinant mouse Ephrin B2 protein (His tag) (AB276883)
Measured by its ability to compete with mouse EFNB2-Fc for binding to immobilized mouse EPHB4 in a functional ELISA assay.
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant mouse Ephrin B2 protein (His tag) (AB276883)
SDS-PAGE analysis of ab276883
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Ephrin-B2 serves as critical mediator for vascular development and nervous system maturation. It is an important player in angiogenesis where it functions through interaction with EphB receptors to regulate blood vessel formation and remodeling. Ephrin-B2 part of the larger ephrin family often acts in concert with other ephrins and Eph receptors to form signaling complexes that coordinate cell positioning and tissue architecture.
Pathways
The action of ephrin-B2 integrates into the Eph/ephrin signaling pathway and the VEGF signaling pathway. These pathways are important for cellular guidance and migration particularly in developing tissues. Ephrin B2's interaction with proteins like VEGF and its receptors emphasizes its role in angiogenic processes. Furthermore Ephrin-B2 interacts with other Eph receptor proteins to modulate cellular responses essential for proper vascular and neural functions.
Specifications
Form
Lyophilized
General info
Function
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
Sequence similarities
Belongs to the ephrin family.
Post-translational modifications
Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
Target data
Complementary Products
Product promise
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