Recombinant mouse ErbB3 / HER3 protein (His tag)
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Recombinant mouse ErbB3 / HER3 protein (His tag) is a Mouse Fragment protein, in the 1 to 641 aa range, expressed in HEK 293 cells, with >93%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.
View Alternative Names
Receptor tyrosine-protein kinase erbB-3, Glial growth factor receptor, Proto-oncogene-like protein c-ErbB-3, Erbb3
- FuncS
Supplier Data
Functional Studies - Recombinant mouse ErbB3 / HER3 protein (His tag) (AB276962)
Measured by its binding ability in a functional ELISA.
1. Immobilized mouse ErbB3-His at 10 μg/ml (100 μl/well) can bind biotinylated human NRG1 (isoform Beta1) with a linear range of 0.018-0.125 μg/ml.
2. Immobilized mouse ErbB3-His at 10 μg/ml (100 μl/well) can bind biotinylated human NRG1 (aa 2-246)-Fc with a linear range of 6.25-100 ng/ml.
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant mouse ErbB3 / HER3 protein (His tag) (AB276962)
SDS-PAGE analysis of ab276962
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Form
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
HER3 is essential for activating important signaling pathways that regulate proliferation differentiation and survival. The ErbB3 protein forms heterodimers with other ErbB family members such as ErbB2 (HER2) which is necessary for its signaling capability. The HER3 protein is abundant in heart and nervous tissues indicating its role in cardiovascular and neurological functions. Its activation modulates gene expression through downstream effectors mediated by dimerization.
Pathways
HER3 plays a pivotal role in the PI3K/Akt and MAPK signaling pathways. These pathways are fundamental in cellular responses like growth and survival. HER3 serves as a major partner for HER2 in these signaling cascades enhancing downstream signaling effects. HER3's connection to these pathways makes it a critical node collaborating closely with proteins such as HER2 and EGFR to maintain efficient communication and function within these networks.
General info
Function
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Post-translational modifications
Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.
Target data
Product promise
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