Recombinant Mouse ESAM protein (His tag) is a Mouse Fragment protein, in the 1 to 251 aa range, expressed in HEK 293, with >92% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >92% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M I L Q A G T P E T S L L R V L F L G L S T L A A F S R A Q M E L H V P P G L N K L E A V E G E E V V L P A W Y T M A R E E S W S H P R E V P I L I W F L E Q E G K E P N Q V L S Y I N G V M T N K P G T A L V H S I S S R N V S L R L G A L Q E G D S G T Y R C S V N V Q N D E G K S I G H S I K S I E L K V L V P P A P P S C S L Q G V P Y V G T N V T L N C K S P R S K P T A Q Y Q W E R L A P S S Q V F F G P A L D A V R G S L K L T N L S I A M S G V Y V C K A Q N R V G F A K C N V T L D V M T G S K A A
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Can mediate aggregation most likely through a homophilic molecular interaction.
Alternative names
Esam1, Esam, Endothelial cell-selective adhesion molecule
Recommended products
Recombinant Mouse ESAM protein (His tag) is a Mouse Fragment protein, in the 1 to 251 aa range, expressed in HEK 293, with >92% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >92% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q925F2-1
- Animal free
- No
- Species
- Mouse
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M I L Q A G T P E T S L L R V L F L G L S T L A A F S R A Q M E L H V P P G L N K L E A V E G E E V V L P A W Y T M A R E E S W S H P R E V P I L I W F L E Q E G K E P N Q V L S Y I N G V M T N K P G T A L V H S I S S R N V S L R L G A L Q E G D S G T Y R C S V N V Q N D E G K S I G H S I K S I E L K V L V P P A P P S C S L Q G V P Y V G T N V T L N C K S P R S K P T A Q Y Q W E R L A P S S Q V F F G P A L D A V R G S L K L T N L S I A M S G V Y V C K A Q N R V G F A K C N V T L D V M T G S K A A
- Accession
- Q925F2
- Protein length
- Fragment
- Predicted molecular weight
- 25.6 kDa
- Amino acids
- 1 to 251
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Can mediate aggregation most likely through a homophilic molecular interaction.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ESAM also known as Endothelial Cell-Selective Adhesion Molecule is part of the immunoglobulin superfamily and is typically found on the surface of endothelial cells. It has a mass of roughly 44 kDa. The ESAM protein is expressed predominantly in vascular and lymphatic endothelial cells but can also be found in platelets. ESAM is important for cell adhesion playing a role in maintaining cell junctions. Through interaction with other proteins ESAM contributes to the structural integrity of blood vessels.
- Biological function summary
ESAM influences vascular stability and permeability. It participates in the formation of endothelial tight junctions being an important component of cell junction complexes. In endothelial cells ESAM enhances barrier function impacting the movement of molecules and cells between the bloodstream and surrounding tissues. Its expression is essential for the organization of other junctional proteins such as claudins and occludins indicating a synergistic role within cell junctions.
- Pathways
The ESAM protein is involved in the regulation of vascular integrity and immune response pathways. Particularly it interacts with signaling components of the vascular endothelial growth factor (VEGF) pathway which is important in angiogenesis. Additionally ESAM modulates the activation of PI3K/Akt signaling promoting cell survival and proliferation. Through its associations ESAM works alongside other proteins such as VE-cadherin highlighting its integrative role in vascular function.
- Associated diseases and disorders
ESAM has shown a connection to cancer progression and inflammatory diseases. In tumors aberrant ESAM expression correlates with increased tumor angiogenesis and metastasis partly due to its influence on endothelial cell permeability and migration. ESAM also relates to atherosclerosis interacting with proteins like ICAM-1 which are involved in leukocyte adhesion and vascular inflammation. Understanding its expression and function in these conditions can help in developing targeted therapies.
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1 product image
SDS-PAGE - Recombinant Mouse ESAM protein (His tag) (ab276956)
SDS-PAGE analysis of ab276956
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