Recombinant Mouse Fc receptor, IgG, low affinity IV protein (His tag)

Specifications

Form

Lyophilized

General info

Function

Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG) (PubMed : 16039578). Binds with intermediate affinity to both IgG2a and IgG2b (PubMed : 16039578, PubMed : 17558411, PubMed : 19795417). Can bind to IgG2a and IgG2b monomers (PubMed : 18949059). Does not display binding to IgG1 or IgG3 (PubMed : 16039578). Recognizes neutralizing virus-specific IgGs displayed on the cell surface of infected cells and triggers antibody-dependent cellular cytotoxicity (ADCC). Confers protection to lethal influenza virus infection (PubMed : 24412922). On splenic dendritic cells, uptakes antigen immune complexes and efficiently divert them into MHC class I and II antigen presentation pathways to provide for superior priming of CD4-positive and CD8-positive T cell immune responses (PubMed : 28389502). Mediates neutrophil activation by IgG complexes redundantly with FCGR2A (PubMed : 18097064). Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed : 25824719). Also acts as a receptor for the Fc region of immunoglobulin epsilon (IgE) (PubMed : 17558411, PubMed : 18949059). Binds with low affinity to both the a and b allotypes of IgE (PubMed : 18949059). Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed : 17558411). Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed : 18949059). Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of pro-inflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed : 17558411, PubMed : 18949059). Mediates enhanced ADCC in response to afucosylated IgGs (PubMed : 34485821).

Post-translational modifications

N-glycosylated.. Phosphorylated following receptor ligation.