Recombinant Mouse FGF21 protein is a Mouse Full Length protein, expressed in Escherichia coli, with >95% purity and suitable for ELISA, WB.
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- Cell death & disease 14:3112023FGF21-FGFR1 controls mitochondrial homeostasis in cardiomyocytes by modulating the degradation of OPA1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBing Yan,Zhu Mei,Yaohan Tang,Haixu Song,Hanlin Wu,Quanmin Jing,Xiaolin Zhang,Chenghui Yan,Yaling HanPubMed 37156793
- Journal of cellular and molecular medicine 24:4992-50062020FGF21 induces autophagy-mediated cholesterol efflux to inhibit atherogenesis via RACK1 up-regulation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLin Xiaolong et. al.PubMed 32227589
- The Journal of nutrition 146:184-902016Fibroblast Growth Factor 21 (Fgf21) Gene Expression Is Elevated in the Liver of Mice Fed a High-Carbohydrate Liquid Diet and Attenuated by a Lipid Emulsion but Is Not Upregulated in the Liver of Mice Fed a High-Fat Obesogenic Diet.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLei Hao et. al.PubMed 26764334
- Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 34:658-712014Fibroblast growth factor 21 protects against high glucose induced cellular damage and dysfunction of endothelial nitric-oxide synthase in endothelial cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiao-Mei Wang,Shuang-Shuang Song,Hang Xiao,Pan Gao,Xue-Jun Li,Liang-Yi SiPubMed 25170746
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
A Y P I P D S S P L L Q F G G Q V R Q R Y L Y T D D D Q D T E A H L E I R E D G T V V G A A H R S P E S L L E L K A L K P G V I Q I L G V K A S R F L C Q Q P D G A L Y G S P H F D P E A C S F R E L L L E D G Y N V Y Q S E A H G L P L R L P Q K D S P N Q D A T S W G P V R F L P M P G L L H E P Q D Q A G F L P P E P P D V G S S D P L S M V E P L Q G R S P S Y A S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity.
Alternative names
Fibroblast growth factor 21, FGF-21, Fgf21
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Recombinant Mouse FGF21 protein is a Mouse Full Length protein, expressed in Escherichia coli, with >95% purity and suitable for ELISA, WB.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q9JJN1-1
- Animal free
- No
- Species
- Mouse
- Reconstitution
- Reconstitute at 0.5 mg/mL in water
- Concentration
- Storage buffer
Constituents: 0.242% Tris, 0.116% Sodium chloride
Sequence info
Amino acid sequence
- A Y P I P D S S P L L Q F G G Q V R Q R Y L Y T D D D Q D T E A H L E I R E D G T V V G A A H R S P E S L L E L K A L K P G V I Q I L G V K A S R F L C Q Q P D G A L Y G S P H F D P E A C S F R E L L L E D G Y N V Y Q S E A H G L P L R L P Q K D S P N Q D A T S W G P V R F L P M P G L L H E P Q D Q A G F L P P E P P D V G S S D P L S M V E P L Q G R S P S Y A S
- Accession
- Q9JJN1
- Protein length
- Full Length
- Nature
- Recombinant
Specifications
- Form
- Lyophilized
General info
- Function
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity.
- Sequence similarities
Belongs to the heparin-binding growth factors family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Storage information
- Avoid freeze / thaw cycle
Notes
Product is NOT sterile! Please filter the product by an appropriate sterile filter before using it in cell culture.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FGF21 or fibroblast growth factor 21 is an important metabolic regulator. It is a member of the fibroblast growth factor family but unlike many others FGF21 functions mainly in endocrine signaling. The molecular weight of FGF21 is approximately 22 kDa. This protein is expressed in tissues such as the liver adipose tissue and pancreas. Because of its endocrine roles FGF21 travels through the bloodstream to exert its functions on distant organs.
- Biological function summary
FGF21 influences glucose and lipid metabolism. It does not act as part of a larger protein complex. Instead it directly affects metabolic processes enhancing insulin sensitivity and lipid oxidation while reducing body weight. These actions help maintain energy balance and homeostasis making FGF21 an important player in metabolic control.
- Pathways
FGF21 plays a significant role in the insulin signaling pathway and PPARγ coactivator 1α (PGC-1α) pathway. These pathways regulate cellular energy metabolism and mitochondrial biogenesis respectively. FGF21 interacts with other molecules such as PPARα (peroxisome proliferator-activated receptor alpha) to exert its effects demonstrating its integration into broader metabolic networks. FGF21's interaction with these pathways highlights its function in energy utilization and storage.
- Associated diseases and disorders
FGF21 has connections to conditions such as obesity and type 2 diabetes. Its role in improving insulin sensitivity and promoting lipid oxidation makes it a molecule of interest in combating metabolic syndrome. FGF21 also has a relationship with hepatic proteins such as insulin receptor substrates (IRS) which play roles in liver functioning. Understanding these relationships offers insights into potential therapeutic strategies targeting metabolic disorders.
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1 product image
SDS-PAGE - Recombinant Mouse FGF21 protein (ab63277)
LANES:
1. MW marker – 14, 21, 31, 45, 66, 97 kDa
2. reduced and heated sample, 5μg/lane
3. non-reduced and non-heated sample, 5μg/lane
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