Recombinant mouse FGF4 protein (Active) is a Mouse Full Length protein, in the 30 to 202 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, FuncS, HPLC.
A P N G T R H A E L G H G W D G L V A R S L A R L P V A A Q P P Q A A V R S G A G D Y L L G L K R L R R L Y C N V G I G F H L Q V L P D G R I G G V H A D T R D S L L E L S P V Q R G V V S I F G V A S R F F V A M S S R G K L F G V P F F T D E C K F K E I L L P N N Y N A Y E S Y A Y P G M F M A L S K N G R T K K G N R V S P T M K V T H F L P R L
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Is essential for survival of the postimplantation mouse embryo. Required for normal limb and cardiac valve development during embryogenesis. May play a role in embryonic molar tooth bud development via inducing the expression of MSX1, MSX2 and MSX1-mediated expression of SDC1 in dental mesenchyme cells (PubMed:8898217).
Fgf-4, Kfgf, Fgf4, Fibroblast growth factor 4, FGF-4, Heparin-binding growth factor 4, K-fibroblast growth factor, HBGF-4
Recombinant mouse FGF4 protein (Active) is a Mouse Full Length protein, in the 30 to 202 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, FuncS, HPLC.
Constituents: 0.58% Sodium chloride, 0.16% Sodium phosphate
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Is essential for survival of the postimplantation mouse embryo. Required for normal limb and cardiac valve development during embryogenesis. May play a role in embryonic molar tooth bud development via inducing the expression of MSX1, MSX2 and MSX1-mediated expression of SDC1 in dental mesenchyme cells (PubMed:8898217).
Belongs to the heparin-binding growth factors family.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
The FGF4 protein also known as fibroblast growth factor 4 is an important player in cell proliferation differentiation and survival. It is part of the fibroblast growth factor family which consists of over 20 known members. The FGF4 protein has a mass of approximately 22 kDa. Researchers observe its expression in various tissues including the embryo and certain adult tissues where it contributes to developmental processes and tissue repair. FGF4 signalling plays a significant role in embryogenesis.
FGF4 protein regulates pathways involved in cell development and morphogenesis. It particularly influences the formation of limbs and the development of the nervous system. FGF4 usually functions as a part of signaling complexes interacting with its specific receptors on the cell surface. These interactions will lead to a cascade of downstream signaling events that modulate gene expression and cellular behavior.
FGF4 engages with multiple signaling pathways notably the MAPK/ERK pathway and the PI3K/AKT pathway. Through these pathways FGF4 protein orchestrates cellular responses important for proper tissue organization and differentiation. It often functions alongside other proteins like FGF2 and FGF8 which share overlapping roles in similar developmental and cellular processes. These interactions underline the complexity and redundancy within the fibroblast growth factor family in ensuring robust biological outcomes.
Dysregulation of FGF4 protein associates with conditions like cancer and developmental defects. Overactive FGF4 signaling has been linked to tumor growth and progression as it can drive unchecked cellular proliferation and survival. Furthermore altered FGF4 expression may relate to syndromes affecting limb development. In the context of these diseases FGF4 can interact with proteins such as FGFR1 leading to aberrant signaling pathways contributing to pathogenesis.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com