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AB238299

Recombinant mouse FGF9/GAF protein (Active)

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Recombinant mouse FGF9/GAF protein (Active) is a Mouse Fragment protein, in the 3 to 208 aa range, expressed in Escherichia coli, with >95%, <1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.

View Alternative Names

Fgf-9, Fgf9, Fibroblast growth factor 9, FGF-9, Glia-activating factor, HBGF-9, GAF

2 Images
Functional Studies - Recombinant mouse FGF9/GAF protein (Active) (AB238299)
  • FuncS

Supplier Data

Functional Studies - Recombinant mouse FGF9/GAF protein (Active) (AB238299)

Induced proliferation of NR6R-3T3 cells.

SDS-PAGE - Recombinant mouse FGF9/GAF protein (Active) (AB238299)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant mouse FGF9/GAF protein (Active) (AB238299)

Recombinant mouse FGF9 protein (Active) (ab238299) used at 1 μg.

4-20% Tris-Glycine gel, stained with Coomassie Blue.

Lane 1 : Reducing conditions.

Lane 2 : Non-reducing conditions.

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

<1 EU/µg

Expression system

Escherichia coli

Tags

Tag free

Applications

FuncS, SDS-PAGE

applications

Biologically active

Yes

Biological activity

3T3 proliferation ED50 ≤ 10 ng/mL (≥ 1.0 x 10^5 units/mg).

Accession

P54130

Animal free

Yes

Carrier free

Yes

Species

Mouse

Reconstitution

reconstitute with water at 0.1mg/mL

Storage buffer

Constituents: 0.16% Sodium phosphate

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MPLGEVGSYFGVQDAVPFGNVPVLPVDSPVLLNDHLGQSEAGGLPRGPAVTDLDHLKGILRRRQLYCRTGFHLEIFPNGTIQGTRKDHSRFGILEFISIAVGLVSIRGVDSGLYLGMNEKGELYGSEKLTQECVFREQFEENWYNTYSSNLYKHVDTGRRYYVALNKDGTPREGTRTKRHQKFTHFLPRPVDPDKVPELYKDILSQS","proteinLength":"Fragment","predictedMolecularWeight":"23.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":208,"aminoAcidStart":3,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P54130","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
True
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FGF9 also known as GAF is a member of the fibroblast growth factor family. The FGF9 protein has a molecular mass of approximately 23 kDa. It is commonly expressed in the brain kidney and lungs during fetal development. The FGF9 protein functions as a signaling molecule influencing cell proliferation and differentiation which are essential for proper tissue formation and organogenesis.
Biological function summary

FGF9 contributes to important processes in the development and maintenance of several tissues. It is not known to be part of a larger complex. FGF9 regulates cellular activities such as proliferation and differentiation through its interaction with specific receptors on the cell surface. Its role is significant in skeletal and nervous system development where it ensures proper maturation and function of these systems.

Pathways

The FGF9 protein participates in the MAPK/ERK and PI3K/AKT signaling pathways. These pathways are important for cell survival proliferation and differentiation. FGF9 interacts closely with other fibroblast growth factors such as FGF2 to ensure effective signaling cascades. These interactions affect various cellular responses and contribute to the normal development of multiple organ systems.

Alterations in FGF9 expression can be linked to conditions such as lung fibrosis and cancer. Aberrant FGF9 signaling can contribute to uncontrolled cell proliferation and fibrosis formation. The GAF protein's dysregulation may involve interactions with receptor proteins including FGFR2 in these pathological processes. Understanding FGF9's role in these diseases helps in developing targeted therapeutic strategies.
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Specifications

Form

Lyophilized

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General info

Function

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.

Sequence similarities

Belongs to the heparin-binding growth factors family.

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Product protocols

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Target data

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
See full target information Fgf9
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